S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
MyD88 Signaling Inhibits Protective Immunity to the Gastrointestinal Helminth Parasite Heligmosomoides polygyrus
Lisa A. Reynolds,Yvonne Harcus,Katherine A. Smith,Lauren M. Webb,James P. Hewitson,Ewan A. Ross,Sheila Brown,Satoshi Uematsu,Shizuo Akira,David Gray,Mohini Gray,Andrew S. MacDonald,Adam F. Cunningham,Rick M. Maizels +13 more
TL;DR: It is reported that C57BL/6 mice lacking the adapter protein MyD88, which mediates signaling by TLRs and IL-1 family members, showed enhanced immunity to H. polygyrus infection, and type 1 IFN receptor signaling may provide pathways to impede granuloma formation in vivo.
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Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza.
Daisuke Fujikura,Satoko Chiba,Daisuke Muramatsu,Mika Kazumata,Yosuke Nakayama,Taro Kawai,Shizuo Akira,Hiroshi Kida,Tadaaki Miyazaki +8 more
TL;DR: It is demonstrated that FasL is induced after the viral infection, and inhibition of the Fas/FasL signal by treatment with a recombinant decoy receptor for FasL (Fas-Fc) increases the survival rate of mice after lethal infection of influenza A virus as well as functional mutation ofThe FasL gene in gld/gld mice.
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Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis
Journal ArticleDOI
Control of RNA Stability in Immunity.
Shizuo Akira,Kazuhiko Maeda +1 more
TL;DR: In this article, RNA-binding proteins (RBPs) bind cis-regulatory elements in the 3' untranslated regions of the mRNA and regulate various biological processes, including inflammatory and immune responses.
Journal ArticleDOI
Macrophage migration inhibitory factor contributes to the development of acute dextran sulphate sodium-induced colitis in Toll-like receptor 4 knockout mice.
Tatsuya Ohkawara,Hiroshi Takeda,Jun Nishihira,Kencho Miyashita,M. Nihiwaki,Yoh Ishiguro,Kiyoshi Takeda,Shizuo Akira,Toshihiko Iwanaga,T. Sugiyama,Masahiro Asaka +10 more
TL;DR: Evidence is provided that MIF plays a critical role in the development of acute DSS‐induced colitis with regard to the biological actions of macrophage migration inhibitory factor using TLR4 null (–/–) mice.