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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Differential contribution of osteoclast- and osteoblast-lineage cells to CpG-oligodeoxynucleotide (CpG-ODN) modulation of osteoclastogenesis.
TL;DR: CpG‐ODNs modulate osteoclast differentiation through Toll‐like receptor 9 (TLR9) through activation of TLR9 on both osteocline precursors and osteoblasts and is found to be more important for this activity than Osteoclastic TLR 9.
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Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in mouse primary cultured glial cells.
TL;DR: The present results point to the important role of bacterial DNA by acting on glial cells to operate brain immune function as well as the MyD88-p38 MAP kinase-dependent mechanisms.
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Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca2+ levels
Takako Takemiya,Kiyoshi Matsumura,Hiroko Sugiura,Shin Yasuda,Satoshi Uematsu,Shizuo Akira,Kanato Yamagata +6 more
TL;DR: It is found that endothelial mPGES-1 produced PGE(2) that enhanced astrocytic Ca(2+) levels via EP3 receptors and increased Ca( 2+)-dependent glutamate release, aggravating neuronal injury.
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Colonic Patches Direct the Cross-Talk Between Systemic Compartments and Large Intestine Independently of Innate Immunity
Sun-Young Chang,Hye-Ran Cha,Satoshi Uematsu,Shizuo Akira,Osamu Igarashi,Hiroshi Kiyono,Mi-Na Kweon +6 more
TL;DR: The results suggest the possibility that cross-talk could occur between the large intestine and the systemic immune compartments via the colonic patches without the assistance of innate immunity.
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Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension.
Jiegen Chen,Josepmaria Argemi,Gemma Odena,Mingjiang Xu,Yan Cai,Veronica Massey,Austin Parrish,Rajanikanth Vadigepalli,José Altamirano,Joaquín Cabezas,Pere Ginès,Juan Caballería,Natasha T. Snider,Pau Sancho-Bru,Shizuo Akira,Ivan Rusyn,Bin Gao,Ramon Bataller,Ramon Bataller +18 more
TL;DR: LCN2 contributes to liver fibrosis and portal hypertension in AH and could represent a new therapeutic target in patients with AH.