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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
Satoshi Uematsu,Kosuke Fujimoto,Myoung Ho Jang,Bo-Gie Yang,Yun-Jae Jung,Mika Nishiyama,Shintaro Sato,Tohru Tsujimura,Masafumi Yamamoto,Yoshifumi Yokota,Hiroshi Kiyono,Masayuki Miyasaka,Ken Ishii,Shizuo Akira +13 more
TL;DR: These findings demonstrate unique properties of LPDCs and the importance of TLR5 for adaptive immunity in the intestine and positively regulated the differentiation interleukin 17–producing T helper cells.
Journal ArticleDOI
Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.
Anne Krug,Gary D. Luker,Gary D. Luker,Winfried Barchet,Winfried Barchet,David A. Leib,David A. Leib,Shizuo Akira,Shizuo Akira,Marco Colonna,Marco Colonna +10 more
TL;DR: Though TLR9/MyD88-deficiency abrogates IPC responses to HSV-1 in vitro, mice lacking either MyD88 orTLR9 are capable of controlling HSV -1 replication in vivo after local infection, demonstrating that TLR 9- and MyD 88-independent pathways in cells other than IPCs can effectively compensate for defective IPC responders.
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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
Tatsuya Saitoh,Naonobu Fujita,Takuya Hayashi,Keigo Takahara,Takashi Satoh,Hanna Lee,Hanna Lee,Kohichi Matsunaga,Shun Kageyama,Hiroko Omori,Takeshi Noda,Naoki Yamamoto,Taro Kawai,Ken Ishii,Osamu Takeuchi,Tamotsu Yoshimori,Shizuo Akira +16 more
TL;DR: It is demonstrated that dynamic membrane traffic mediates the sequential translocation and assembly of STING, both of which are essential processes required for maximal activation of the innate immune response triggered by dsDNA.
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Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus *
Loïc Guillot,Ronan Le Goffic,Sarah Bloch,Nicolas Escriou,Shizuo Akira,Michel Chignard,Mustapha Si-Tahar +6 more
TL;DR: It is demonstrated that TLR3 contributes directly to the immune response of respiratory epithelial cells to influenza A virus and dsRNA, and a molecular mechanism by which these stimuli induce epithelial cell activation is proposed.
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Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
Takuma Misawa,Michihiro Takahama,Tatsuya Kozaki,Hanna Lee,Jian Zou,Tatsuya Saitoh,Shizuo Akira +6 more
TL;DR: It is shown that microtubules mediated assembly of the NLRP3 inflammasome, and the creation of optimal sites for signal transduction by microtubule is required for activation of the entire NLRP2 inflammaome.