S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
Papers
More filters
Journal ArticleDOI
Contribution of IL-33–activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice
Koubun Yasuda,Taichiro Muto,Tatsukata Kawagoe,Makoto Matsumoto,Yuki Sasaki,Kazufumi Matsushita,Yuko Taki,Shizue Futatsugi-Yumikura,Hiroko Tsutsui,Ken Ishii,Tomohiro Yoshimoto,Shizuo Akira,Kenji Nakanishi +12 more
TL;DR: The relevant roles of endogenous IL-33 for Strongyloides venezuelensis infection-induced lung eosinophilic inflammation are shown by using Il33−/− mice and IL- 33–stimulated NH cells induce lung eOSinophobic inflammation and might aid to expel infected worms in the lungs.
Journal ArticleDOI
Differential involvement of IFN-β in Toll-like receptor-stimulated dendritic cell activation
TL;DR: In this article, the authors analyzed whether type I IFN is involved in TLR4-induced responses and showed that TLR9 signaling can also induce expression of IFN-b and IFNinducible genes, and up-regulation of CD40.
Journal ArticleDOI
Toll-Like Receptor-2 Modulates Ventricular Remodeling After Myocardial Infarction
Tetsuro Shishido,Naoki Nozaki,Seiji Yamaguchi,Yoko Shibata,Joji Nitobe,Takuya Miyamoto,Hiroki Takahashi,Takanori Arimoto,Kunihiko Maeda,Mitsunori Yamakawa,Osamu Takeuchi,Shizuo Akira,Yasuchika Takeishi,Isao Kubota +13 more
TL;DR: Data suggest that TLR-2 plays an important role in ventricular remodeling after myocardial infarction and indicates that Toll-like receptors are activated by endogenous signals, such as heat shock proteins and oxidative stress.
Journal Article
Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.
TL;DR: Sequences similar to transcriptional enhancer elements such as the c-fos serum responsive element and the consensus sequences for cAMP induction, activator protein 1 binding, and the glucocorticoid receptor binding are identified within the highly conserved 5'-flanking regions of the genes from the two species.
Journal ArticleDOI
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking
Takeshi Kondo,Junya Kobayashi,Tatsuya Saitoh,Kenta Maruyama,Ken Ishii,Glen N. Barber,Kenshi Komatsu,Shizuo Akira,Taro Kawai +8 more
TL;DR: It is shown that the DNA damage sensor, meiotic recombination 11 homolog A (MRE11), serves as a cytosolic sensor for dsDNA, and that the MRE11–RAD50 complex plays important roles in recognition of ds DNA and initiation of STING-dependent signaling, in addition to its role in DNA-damage responses.