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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4
Thierry Roger,Céline Froidevaux,Didier Le Roy,Marlies Knaup Reymond,Anne-Laure Chanson,Davide Mauri,Kim Burns,Beat M. Riederer,Shizuo Akira,Thierry Calandra +9 more
TL;DR: Anti-TLR4 antibodies inhibited intracellular signaling, markedly reduced cytokine production, and protected mice from lethal endotoxic shock and E. coli sepsis when administered in a prophylactic and therapeutic manner up to 13 h after the onset of bacterial sepsi.
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IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions.
Hiroshi Konishi,Hiroko Tsutsui,Takaaki Murakami,Shizue Yumikura-Futatsugi,Keiichi Yamanaka,Minoru Tanaka,Yohichiro Iwakura,Noboru Suzuki,Kiyoshi Takeda,Shizuo Akira,Kenji Nakanishi,Hitoshi Mizutani +11 more
TL;DR: AD-like inflammation is initiated by overrelease of IL-18 and accelerated by IL-1, which might provide insight into understanding the pathogenesis of and establishing therapeutics for chronic inflammatory skin diseases including AD.
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U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.
Emina Savarese,Ohk-wha Chae,Simon Trowitzsch,Gert Weber,Berthold Kastner,Shizuo Akira,Hermann Wagner,Roland M. Schmid,Stefan Bauer,Anne Krug +9 more
TL;DR: It is shown that murine PDCs are activated by purified U1snRNP/anti-Sm ICs to produce IFN-alpha and proinflammatory cytokines and to up-regulate costimulatory molecules.
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Roles of Toll-like receptors in innate immune responses.
Kiyoshi Takeda,Shizuo Akira +1 more
TL;DR: A family of Toll‐like receptors (TLRs) was identified, and crucial roles for these receptors in the recognition of microbial components have been elucidated, and these receptors control both innate and adaptive immune responses.
Journal ArticleDOI
Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice.
Hiroko Tsutsui,Nobuhiko Kayagaki,Keisuke Kuida,Hiroki Nakano,Nobuki Hayashi,Kiyoshi Takeda,Kiyoshi Matsui,Shin-ichiro Kashiwamura,Toshikazu Hada,Shizuo Akira,Hideo Yagita,Haruki Okamura,Kenji Nakanishi +12 more
TL;DR: Results indicate a caspase-1-independent pathway of IL-18 secretion from FasL-stimulated macrophages and its critical involvement in FasL/FasL-induced liver injury.