S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Toll-like Receptor 7-Dependent Loss of B Cell Tolerance in Pathogenic Autoantibody Knockin Mice
Robert Berland,Luis Fernandez,Elina Kari,Jin-Hwan Han,Ina Lomakin,Shizuo Akira,Henry H. Wortis,John F. Kearney,Angelo A. Ucci,Thereza Imanishi-Kari +9 more
TL;DR: It is demonstrated that the particular threat of nucleic acid-containing autoantigens lies in their ability to bind both antigen receptor and TLR7, and production of these autoantibodies was sufficient to cause kidney pathology in these mice.
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Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway
Motoharu Awazawa,Kohjiro Ueki,Kazunori Inabe,Toshimasa Yamauchi,Naoto Kubota,Kazuma Kaneko,Masatoshi Kobayashi,Aya Iwane,Takayoshi Sasako,Yukiko Okazaki,Mitsuru Ohsugi,Iseki Takamoto,Satoshi Yamashita,Hiroshi Asahara,Shizuo Akira,Masato Kasuga,Takashi Kadowaki +16 more
TL;DR: In this article, the authors showed that adiponectin upregulates IRS-2 through activation of signal transducers and activators of transcription-3 (STAT3), which is associated with IL-6 production.
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Plasmodium berghei Infection in Mice Induces Liver Injury by an IL-12- and Toll-Like Receptor/Myeloid Differentiation Factor 88-Dependent Mechanism
Keishi Adachi,Hiroko Tsutsui,Shin-ichiro Kashiwamura,Ekihiro Seki,Hiroki Nakano,Osamu Takeuchi,Kazuyoshi Takeda,Ko Okumura,Luc Van Kaer,Haruki Okamura,Shizuo Akira,Kenji Nakanishi +11 more
TL;DR: The results indicate that the liver injury induced by P. berghei infection of mice inducesactivation of the TLR-MyD88 signaling pathway which results in IL-12 production and activation of the perforin-dependent cytotoxic activities of MHC-unrestricted hepatic lymphocytes.
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Regulation of innate immune responses by autophagy-related proteins
Tatsuya Saitoh,Shizuo Akira +1 more
TL;DR: These studies reveal that autophagy-related proteins are involved in the innate immune response and may contribute to the development of inflammatory disorders.
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Sequential MyD88-Independent and -Dependent Activation of Innate Immune Responses to Intracellular Bacterial Infection
Natalya V. Serbina,William A. Kuziel,Richard A. Flavell,Shizuo Akira,Barrett J. Rollins,Eric G. Pamer +5 more
TL;DR: The results indicate that distinct microbial signals activate innate immune responses in an ordered, step-wise fashion, providing a mechanism to specify and modulate antimicrobial effector functions.