S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism.
Silvia Stockinger,Benjamin Reutterer,Barbara Schaljo,Carola Schellack,Sylvia Brunner,Tilo Materna,Masahiro Yamamoto,Shizuo Akira,Tadatsugu Taniguchi,Peter J. Murray,Mathias Müller,Thomas Decker +11 more
TL;DR: It is proposed that IRF3 is a convergence point for signals derived from structurally unrelated intracellular pathogens, and that L. monocytogenes stimulates a novel TLR- and Nod2-independent pathway to target IRF 3 and the type I IFN genes.
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MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.
Thomas Delale,André Paquin,Carine Asselin-Paturel,Marc Dalod,Géraldine Brizard,Elizabeth E. M. Bates,Philippe Kastner,Susan Chan,Shizuo Akira,Alain Vicari,Christine A. Biron,Giorgio Trinchieri,Francine Brière +12 more
TL;DR: A critical requirement of TLR9 in the process of MCMV sensing to assure rapid antiviral responses, coordinated with other TLR-dependent and -independent events that are sufficient to establish adaptive immunity are demonstrated.
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Toll-like receptor 6-independent signaling by diacylated lipopeptides.
Ute Buwitt-Beckmann,Holger Heine,Karl-Heinz Wiesmüller,Günther Jung,Roland Brock,Shizuo Akira,Artur J. Ulmer +6 more
TL;DR: The results indicate that both the lipid and the N‐terminal peptides of lipoproteins contribute to the specificity of recognition by TLR2 heteromers and are responsible for the ligand–receptor interaction on host cells.
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Involvement of the Toll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus.
Takayuki Abe,Hiroaki Hemmi,Hironobu Miyamoto,Kohji Moriishi,Shinichi Tamura,Hiroshi Takaku,Shizuo Akira,Yoshiharu Matsuura +7 more
TL;DR: It is shown that AcNPV activates immune cells via the Toll-like receptor 9 (TLR9)/MyD88-dependent signaling pathway, and the internalization of viral DNA via membrane fusion mediated by the viral envelope glycoprotein, as well as endosomal maturation, is necessary for the induction of the innate immune response by Ac NPV.
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Autophagy proteins control goblet cell function by potentiating reactive oxygen species production
Khushbu Patel,Hiroyuki Miyoshi,Wandy L. Beatty,Richard D. Head,Nicole P. Malvin,Ken Cadwell,Jun-Lin Guan,Tatsuya Saitoh,Shizuo Akira,Per Ottar Seglen,Mary C. Dinauer,Herbert W. Virgin,Thaddeus S. Stappenbeck +12 more
TL;DR: Autophagy proteins can control secretory function through ROS, which is in part generated by LC3‐positive vacuole‐associated NADPH oxidases, which provides a novel mechanism by which autophagyprotein can control secretion.