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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Inhibition of RIG-I-Dependent Signaling to the Interferon Pathway during Hepatitis C Virus Expression and Restoration of Signaling by IKKε
Adrien Breiman,Nathalie Grandvaux,Rongtuan Lin,Catherine Ottone,Shizuo Akira,Mitsutoshi Yoneyama,Takashi Fujita,John Hiscott,Eliane F. Meurs +8 more
TL;DR: The partial restoration of the capacity of the host cell to transcribe IFN-β indicates that IKKε expression is able to bypass the HCV-mediated inhibition and restore the innate antiviral response.
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Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines
Qing Zhu,Colt Egelston,Aravindhan Vivekanandhan,Satoshi Uematsu,Shizuo Akira,Dennis M. Klinman,Igor M. Belyakov,Jay A. Berzofsky +7 more
TL;DR: An underlying TLR mechanism governing the functional, nonrandom interplay among TLRs for recognition of combinatorial ligands that may be dangerous to the host is revealed, providing important guidance for design of novel synergistic molecular vaccine adjuvants.
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Activation of TBK1 and IKKε Kinases by Vesicular Stomatitis Virus Infection and the Role of Viral Ribonucleoprotein in the Development of Interferon Antiviral Immunity
Benjamin R. tenOever,Sonia Sharma,Wen Zou,Qiang Sun,Nathalie Grandvaux,Ilkka Julkunen,Hiroaki Hemmi,Midori Yamamoto,Shizuo Akira,Wen-Chen Yeh,Rongtuan Lin,John Hiscott +11 more
TL;DR: Examination of the activation of TBK1 and IKKε kinases by vesicular stomatitis virus (VSV) infection in human lung epithelial A549 cells suggests that intracellular RNP formation contributes to the early recognition of VSV infection, activates the catalytic activity ofTBK1, and induces transcriptional upregulation of IKKα in epithelial cells.
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Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β.
Tadaomi Kawashima,Akemi Kosaka,Huimin Yan,Zijin Guo,Ryosuke Uchiyama,Ryutaro Fukui,Daisuke Kaneko,Yutaro Kumagai,Dong-Ju You,Joaquim Carreras,Satoshi Uematsu,Myoung Ho Jang,Myoung Ho Jang,Osamu Takeuchi,Osamu Takeuchi,Tsuneyasu Kaisho,Shizuo Akira,Kensuke Miyake,Hiroko Tsutsui,Takashi Saito,Ikuko Nishimura,Noriko M. Tsuji +21 more
TL;DR: It is suggested that dsRNA in commensal bacteria contributes to anti-inflammatory and protective immune responses and is identified as a discriminatory sensor to small intestinal commensals by using Toll-like receptor 3.
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Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production.
Kei Yasuda,Christophe Richez,Joseph Walter Maciaszek,Neerja Agrawal,Shizuo Akira,Ann Marshak-Rothstein,Ian R. Rifkin +6 more
TL;DR: It is shown that sera and purified IgG from lupus patients activate mouse DCs to produceIFN-α, IFN-β, and IL-6 and up-regulate costimulatory molecules in a FcγR-dependent manner, indicating the need for a type I IFn-dependent feedback loop in the production of inflammatory cytokines.