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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Toll-like receptors: lessons from knockout mice.
TL;DR: Results show that different TLRs recognize different microbial cell-wall components, and that MyD88 is an essential signalling molecule shared among interleukin-1 receptor/Toll family members.
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IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock
Yoshimitsu Sakao,Kiyoshi Takeda,Hiroko Tsutsui,Tsuneyasu Kaisho,Fumiko Nomura,Haruki Okamura,Kenji Nakanishi,Shizuo Akira +7 more
TL;DR: It is demonstrated that IL-18 is responsible for the progression of endotoxin-induced liver injury as well as down-regulation of endot toxin-induced TNF-alpha production in P. acnes-primed mice.
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Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis
Yasuyuki Kihara,Takuya Matsushita,Yoshihiro Kita,Satoshi Uematsu,Shizuo Akira,Jun Ichi Kira,Satoshi Ishii,Takao Shimizu +7 more
TL;DR: It is reported that microsomal PGE synthase 1 (mPGES-1) plays a key role in experimental autoimmune encephalomyelitis (EAE) and the mPGES -1-PGE2-EPs axis of the AA cascade may exacerbate EAE pathology.
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Pathogenic Vibrio Activate NLRP3 Inflammasome via Cytotoxins and TLR/Nucleotide-Binding Oligomerization Domain-Mediated NF-κB Signaling
Claudia Toma,Naomi Higa,Yukiko Koizumi,Noboru Nakasone,Yasunori Ogura,Andrea J. McCoy,Luigi Franchi,Satoshi Uematsu,Junji Sagara,Shun'ichiro Taniguchi,Hiroko Tsutsui,Shizuo Akira,Jürg Tschopp,Gabriel Núñez,Toshihiko Suzuki +14 more
TL;DR: The results identify the NLRP3 inflammasome as a sensor of Vibrio infections through the action of bacterial cytotoxins and differential activation of innate signaling pathways acting upstream of NF-κB.
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CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.
Norihito Yazawa,Manabu Fujimoto,Shinichi Sato,Kensuke Miyake,Noriko Asano,Yoshinori Nagai,Osamu Takeuchi,Kiyoshi Takeda,Hitoshi Okochi,Shizuo Akira,Thomas F. Tedder,Kunihiko Tamaki +11 more
TL;DR: It is demonstrated that CD19 plays a major role in regulating signal transduction through RP105, a major gram-negative bacterial component that stimulates innate immune response and also induces B-lymphocyte activation.