Shouya Feng

TL;DR: The mechanistic functions of GSDM proteins with respect to their expression and signaling profile in the cell are reviewed, with more focused discussions on inflammasome activation and cell death.

TL;DR: The results reveal that cytosolic sensing of a toxin is central to the innate immune recognition of infection, and therapeutic modulation of this pathway enhances host protection against deadly bacterial infections.

TL;DR: In this article, the role of mammalian cell types and organellar architectures in executing inflammasome responses is highlighted, highlighting the role and importance of mammalian cells and their organellar structures in executing inflammatory and apoptotic responses.

TL;DR: It is shown that NHE and HBL operate synergistically to induce inflammation and show that multiple virulence factors from the same pathogen with conserved function and mechanism of action can be exploited for sensing by a single inflammasome.

TL;DR: Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.