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Shu-Ling Lin

Bio: Shu-Ling Lin is an academic researcher from Soochow University (Taiwan). The author has contributed to research in topics: Monolithic HPLC column & Liquid chromatography–mass spectrometry. The author has an hindex of 14, co-authored 21 publications receiving 513 citations.

Papers
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Journal ArticleDOI
01 Apr 2016-Talanta
TL;DR: The applicability of the developed QuEChERS-capillary LC-MS/MS method was demonstrated by determining the occurrence of CAP, TAP, and FF in various milk and honey samples by simultaneously determining amphenicol antibiotics by capillary liquid chromatography tandem mass spectrometry.

74 citations

Journal ArticleDOI
15 Dec 2009-Talanta
TL;DR: Partitioned dispersive liquid-liquid microextraction (PDLLME), using THF as the dispersive solvent and dichloromethane as the extraction solvent, was utilized to isolate and concentrate phenylurea herbicides from aqueous samples.

70 citations

Journal ArticleDOI
TL;DR: This mini‐review summarizes the utilization of commercial chip‐based LC‐MS systems for determination of small molecules in bioanalytical applications, including drug metabolites and disease/tumor‐associated biomarkers in clinical samples as well as adsorption, distribution, metabolism, and excretion studies of APIs in drug discovery and development.
Abstract: The development and integration of microfabricated liquid chromatography (LC) microchips have increased dramatically in the last decade due to the needs of enhanced sensitivity and rapid analysis as well as the rising concern on reducing environmental impacts of chemicals used in various types of chemical and biochemical analyses. Recent development of microfluidic chip-based LC mass spectrometry (chip-based LC-MS) has played an important role in proteomic research for high throughput analysis. To date, the use of chip-based LC-MS for determination of small molecules, such as biomarkers, active pharmaceutical ingredients (APIs), and drugs of abuse and their metabolites, in clinical and pharmaceutical applications has not been thoroughly investigated. This mini-review summarizes the utilization of commercial chip-based LC-MS systems for determination of small molecules in bioanalytical applications, including drug metabolites and disease/tumor-associated biomarkers in clinical samples as well as adsorption, distribution, metabolism, and excretion studies of APIs in drug discovery and development. The different types of commercial chip-based interfaces for LC-MS analysis are discussed first and followed by applications of chip-based LC-MS on biological samples as well as the comparison with other LC-MS techniques.

55 citations

Journal ArticleDOI
TL;DR: ThisUSAEME method provided detection limits lower than their contaminant levels, which made USAEME an effective sample preparation method for determining organic environmental contaminants, such as CPAs, in river water samples with little consumption of organic solvent.

42 citations

Journal ArticleDOI
01 Mar 2017-Talanta
TL;DR: The applicability of the modified QuEChERS-LC-MS/MS method was demonstrated by determining the occurrence of target sulfonamides in various edible animal tissues for potential food safety analysis.

34 citations


Cited by
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Journal ArticleDOI
TL;DR: This review focuses on the extra steps in sample preparation for application of DLLME in different matrixes such as food, biological fluids and solid samples and its applications in conjunction with different extraction techniques such as solid-phase extraction, solidification of floating organic drop and supercritical fluid extraction are summarized.

851 citations

Journal ArticleDOI
TL;DR: In this article, a brief presentation of the theory of ultrasound assisted extraction (UAE) is given, and the main results in selected applications published in the period 2010-12 are summarized.
Abstract: In recent years, ultrasound-assisted extraction (UAE) has attracted growing interest, as it is an effective method for the rapid extraction of a number of compounds from food and environmental samples, with extraction efficiency comparable to that of classical techniques. In particular, recently, numerous analytical applications of this technique dealt with the extraction of natural compounds and pollutants from food and environmental samples. This review gives a brief presentation of the theory of UAE, discusses recent advances that influence its efficiency, and summarizes the main results in selected applications published in the period 2010–12. There is discussion of the advantages and the disadvantages of UAE and the possibility of coupling UAE with other analytical techniques.

280 citations

Journal ArticleDOI
TL;DR: In this paper, an optimization study on the production of biodiesel from camelina seed oil using alkaline transesterification is presented. And the results of the optimized biodiesel, including density, kinematic viscosity, acid value, etc., were determined and compared with those produced from other oil feedstocks.

277 citations