S
Shu Wang
Researcher at Harvard University
Publications - 17
Citations - 1759
Shu Wang is an academic researcher from Harvard University. The author has contributed to research in topics: Immune system & Second fundamental form. The author has an hindex of 9, co-authored 16 publications receiving 1013 citations. Previous affiliations of Shu Wang include Cornell University.
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Journal ArticleDOI
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
Livnat Jerby-Arnon,Parin Shah,Michael S. Cuoco,Christopher Rodman,Mei-Ju Su,Johannes C. Melms,Rachel Leeson,Abhay Kanodia,Shaolin Mei,Jia-Ren Lin,Shu Wang,Bokang Rabasha,David Liu,Gao Zhang,Claire Margolais,Orr Ashenberg,Patrick A. Ott,Elizabeth I. Buchbinder,Rizwan Haq,F. Stephen Hodi,Genevieve M. Boland,Ryan J. Sullivan,Dennie T. Frederick,Benchun Miao,Tabea Moll,Keith T. Flaherty,Meenhard Herlyn,Russell W. Jenkins,Rohit Thummalapalli,Monika S. Kowalczyk,Israel Cañadas,Bastian Schilling,Bastian Schilling,Adam N.R. Cartwright,Adrienne M. Luoma,Shruti Malu,Patrick Hwu,Chantale Bernatchez,Marie Andrée Forget,David A. Barbie,Alex K. Shalek,Itay Tirosh,Peter K. Sorger,Kai W. Wucherpfennig,Eliezer M. Van Allen,Dirk Schadendorf,Bruce E. Johnson,Asaf Rotem,Asaf Rotem,Orit Rozenblatt-Rosen,Levi A. Garraway,Charles H. Yoon,Charles H. Yoon,Benjamin Izar,Aviv Regev +54 more
TL;DR: A resistance program expressed by malignant cells that is associated with T cell exclusion and immune evasion is identified, and this study provides a high-resolution landscape of ICI-resistant cell states, identifies clinically predictive signatures, and suggests new therapeutic strategies to overcome immunotherapy resistance.
Journal ArticleDOI
Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
Jia-Ren Lin,Benjamin Izar,Shu Wang,Clarence Yapp,Shaolin Mei,Parin Shah,Sandro Santagata,Peter K. Sorger +7 more
TL;DR: Tissue-based cyclic immunofluorescence method for highly multiplexed immuno-fluorescence imaging of formalin-fixed, paraffin-embedded specimens mounted on glass slides, the most widely used specimens for histopathological diagnosis of cancer and other diseases is described.
Posted ContentDOI
Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
Jia-Ren Lin,Benjamin Izar,Shaolin Mei,Shu Wang,Parin Shah,Clarence Yapp,Sandro Santagata,Peter K. Sorger +7 more
TL;DR: Tissue-based cyclic immunofluorescence method for highly multiplexed immuno-fluorescence imaging of formalin-fixed, paraffin-embedded specimens mounted on glass slides, the most widely used specimens for histopathological diagnosis of cancer and other diseases is described.
Journal ArticleDOI
Qualifying Antibodies for Image-Based Immune Profiling and Multiplexed Tissue Imaging
Ziming Du,Ziming Du,Jia-Ren Lin,Rumana Rashid,Rumana Rashid,Zoltan Maliga,Shu Wang,Jon C. Aster,Jon C. Aster,Benjamin Izar,Peter K. Sorger,Sandro Santagata +11 more
TL;DR: This protocol provides step-by-step procedures for confirming the selectivity and specificity of antibodies used in fluorescence-based tissue imaging and for the construction and validation of antibody panels for FFPE tissue sections using cyclic immunofluorescence (t-CyCIF) or other multiplexed imaging methods.
Journal ArticleDOI
Differences in steady-state inactivation between Na channel isoforms affect local anesthetic binding affinity
TL;DR: The results indicate that the greater sensitivity of cardiac tissue to cocaine or lidocaine is not due to a higher affinity of the LA receptor in cardiac Na channels, but that at physiological resting potentials, a greater percentage of hH1 channels than mu 1 channels are in the inactivated (i.e., high-affinity) state.