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Shu-Yu Wang
Researcher at Zhengzhou University
Publications - 6
Citations - 63
Shu-Yu Wang is an academic researcher from Zhengzhou University. The author has contributed to research in topics: Tubulin & Medicine. The author has an hindex of 2, co-authored 4 publications receiving 21 citations.
Papers
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Journal ArticleDOI
Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway.
Jian Song,Qiu-Lei Gao,Bo-Wen Wu,Ting Zhu,Xin-Xin Cui,Cheng-Jun Jin,Shu-Yu Wang,Sheng-Hui Wang,Dong-Jun Fu,Hong-Min Liu,Sai-Yang Zhang,Yan-Bing Zhang,Yongchun Li +12 more
TL;DR: Compound F10 was the first to be reported as a new anticancer agent in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway and binding tightly into the colchicine binding site of β-tubulin.
Journal ArticleDOI
Progress of tubulin polymerization activity detection methods
TL;DR: In this paper, the biological activity detection methods of tubulin polymerization inhibitors are reviewed and a theoretical basis for the further study and selection of methods for tubulin inhibitors is provided.
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Discovery of indoline derivatives as anticancer agents via inhibition of tubulin polymerization
Shu-Yu Wang,Xu Liu,Ling-Wei Meng,Miaomiao Li,Yin-Ru Li,Guang-Xi Yu,Jian Song,Hong-Yu Zhang,Ping Chen,Sai-Yang Zhang,Tao Hu +10 more
TL;DR: In this article, the most active compound 9d was identified as a tubulin inhibitor targeting colchicine binding site with an IC50 value of 3.4 µm.
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Review of NEDDylation inhibition activity detection methods
Shu-Yu Wang,Xu Liu,Yuan Liu,Hong-Yu Zhang,Yan-Bing Zhang,Chong Liu,Jian Song,Jin-Bo Niu,Sai-Yang Zhang +8 more
TL;DR: This review will provide an up-to-date and comprehensive review of the methods for detecting NEDDylation activity that will contribute to NEDdylation inhibitor development.
Journal ArticleDOI
Identification of key genes and pathway related to chemoresistance of small cell lung cancer through an integrative bioinformatics analysis
Fan-Rui Zeng,Xu Zhou,Lingzao Zeng,Jian Sun,Fen He,Wei-Jia Mo,Yang Wen,Shu-Yu Wang,Qin Liu,Lin-Lang Guo +9 more
TL;DR: The top 10 upregulated DELs containing NCRNA00173 may be involved in the regulation of drug resistance in SCLC and may regulate the genes related to the mTOR signaling pathway.