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Shuang Li
Researcher at National Institutes of Health
Publications - 12
Citations - 994
Shuang Li is an academic researcher from National Institutes of Health. The author has contributed to research in topics: RNA & Dyskerin. The author has an hindex of 10, co-authored 11 publications receiving 869 citations. Previous affiliations of Shuang Li include Peking University & Beijing Normal University.
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Journal ArticleDOI
Identification of cross-linked peptides from complex samples
Bing Yang,Yan-Jie Wu,Ming Zhu,Sheng-Bo Fan,Jinzhong Lin,Kun Zhang,Shuang Li,Hao Chi,Yu-Xin Li,Hai-Feng Chen,Shukun Luo,Yue-He Ding,Le-Heng Wang,Zhiqi Hao,Li-Yun Xiu,She Chen,Keqiong Ye,Si-Min He,Meng-Qiu Dong +18 more
TL;DR: pLink as mentioned in this paper is a software for data analysis of cross-linked proteins coupled with mass-spectrometry analysis, which is compatible with multiple homo- or hetero-bifunctional cross-linkers.
Journal ArticleDOI
Biochemical Insights on Degradation of Arabidopsis DELLA Proteins Gained From a Cell-Free Assay System
Feng Wang,Danmeng Zhu,Danmeng Zhu,Xi Huang,Shuang Li,Yi-Nan Gong,Qinfang Yao,Xiangdong Fu,Liu-Min Fan,Xing Wang Deng,Xing Wang Deng +10 more
TL;DR: This in vitro degradation system provides biochemical insights into the regulation of DELLA protein degradation and could be widely adapted for dissecting cellular signaling pathways in which regulated proteolysis is a key recurrent theme.
Journal ArticleDOI
Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase
TL;DR: This work reconstituted functional Saccharomyces cerevisiae H/ACA RNPs with recombinant proteins Cbf5, Nop10, Gar1, and Nhp2 and a two-hairpin H-ACA RNA and revealed significant novel features of eukaryotic H/ ACA RNPs.
Journal ArticleDOI
Structure of the Shq1–Cbf5–Nop10–Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita
TL;DR: The results suggest that Shq1 functions as an assembly chaperone that protects the Cbf5 protein complexes from non‐specific RNA binding and aggregation before assembly of H/ACA RNA.
ComponentDOI
Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions.
Shuang Li,Zhaoming Su,Jean Lehmann,Vassiliki Stamatopoulou,Nikoleta Giarimoglou,Frances E. Henderson,Lixin Fan,Grigore D. Pintilie,Kaiming Zhang,Muyuan Chen,Steven J. Ludtke,Yun-Xing Wang,Constantinos Stathopoulos,Wah Chiu,Wah Chiu,Jinwei Zhang +15 more
TL;DR: Cocrystal and cryo-EM structures of Geobacillus kaustophilus and Bacillus subtilis T-box-tRNA complexes are reported, detailing their multivalent, exquisitely selective interactions and exemplify how higher-order RNA-RNA interactions achieve multivalency and specificity.