Shuji Kishi

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: Human, animal, and in vitro findings shed light on the molecular mechanism of statin-induced myopathy and suggest that atrogin-1 may be a critical mediator of the muscle damage induced by statins.

TL;DR: Although some stress-associated markers are upregulated and minor histological changes are observed during the aging process of zebrafish, these studies together with other evidence of remarkable reproductive and regenerative abilities suggest that zebra fish show very gradual or sub-negligible senescence in vivo.

TL;DR: Zebrafish aging is associated with changes in cognitive responses to emotionally positive and negative experiences, reduced generalization of adaptive associations, increased stereotypic and reduced exploratory behavior and altered temporal entrainment, which would allow the use of powerful molecular biological resources accumulated in the zebrafish field to address the mechanisms of cognitive senescence.