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Shukun Luo
Researcher at Columbia University
Publications - 21
Citations - 1205
Shukun Luo is an academic researcher from Columbia University. The author has contributed to research in topics: Separase & Mutant. The author has an hindex of 11, co-authored 18 publications receiving 1000 citations. Previous affiliations of Shukun Luo include Shanghai Jiao Tong University & University of Minnesota.
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Journal ArticleDOI
Identification of cross-linked peptides from complex samples
Bing Yang,Yan-Jie Wu,Ming Zhu,Sheng-Bo Fan,Jinzhong Lin,Kun Zhang,Shuang Li,Hao Chi,Yu-Xin Li,Hai-Feng Chen,Shukun Luo,Yue-He Ding,Le-Heng Wang,Zhiqi Hao,Li-Yun Xiu,She Chen,Keqiong Ye,Si-Min He,Meng-Qiu Dong +18 more
TL;DR: pLink as mentioned in this paper is a software for data analysis of cross-linked proteins coupled with mass-spectrometry analysis, which is compatible with multiple homo- or hetero-bifunctional cross-linkers.
Journal ArticleDOI
Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain.
Shukun Luo,Liang Tong +1 more
TL;DR: These residues are conserved in the human YTH proteins that also bind m6A RNA, suggesting a conserved mode of recognition.
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An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.
TuAnh Ngoc Huynh,Shukun Luo,Daniel A. Pensinger,John-Demian Sauer,Liang Tong,Joshua J. Woodward +5 more
TL;DR: Using chemical proteomics, the Listeria monocytogenes protein PgpH is identified as a molecular target of c-di-AMP and represents a broadly conserved class of His-Asp -domain phosphodiesterases that are widespread across several taxonomic groups.
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Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State
Adelle P. McFarland,Shukun Luo,Fariha Ahmed-Qadri,Meghan Zuck,Elizabeth F. Thayer,Young Ah Goo,Kevin Hybiske,Liang Tong,Joshua J. Woodward +8 more
TL;DR: Cdn binding to RECON inhibits its enzymatic activity and promotes a proinflammatory, antibacterial state that is distinct from the antiviral state associated with STING activation, and McFarland et al. find that the oxidoreductase RECON acts as a sensor for bacterial cdNs.
Journal ArticleDOI
Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain
Jinping Liu,Shukun Luo,Hongchang Zhao,Ji Liao,Jing Li,Chunying Yang,Bo Xu,David F. Stern,Xingzhi Xu,Keqiong Ye +9 more
TL;DR: It is shown that T4 is phosphorylated primarily by ATM upon DNA damage, and the FHA domain mediates phosphorylation-dependent dimerization of MDC1 in response to DNA damage.