Shuo Su

TL;DR: This review aims to compare and contrast the different HCoVs with regard to epidemiology and pathogenesis, in addition to the virus evolution and recombination events which have, on occasion, resulted in outbreaks amongst humans.

TL;DR: It is proposed, based on the One Health model, that veterinarians and animal specialists should be involved in a cross-disciplinary collaboration in the fight against this epidemic, and suggest a low species barrier for transmission of the virus to farm animals.

TL;DR: The epidemiology, evolution, and recent outbreaks of Aivs in China are reviewed, reasons behind the recent increase in the emergence of novel AIVs are discussed, and warning signs which may point to the emerged of a potentially virulent and highly transmissible AIV to humans are identified.

TL;DR: The different waves of H7N9 regarding their epidemiology, pathogenesis, evolution, and characteristic features are summarized and compared, and factors behind the recent increase in the number of human cases and sudden outbreaks in chickens are speculated on.

TL;DR: X-ray structures of human ACE2 bound to the receptor-binding domain (RBD) of the spike protein (S) from SARS-CoV-2 are used to predict its binding to ACE2 proteins from different animals, including pets, farm animals, and putative intermediate hosts of Sars-Cov-2, and it is found that ACE2 from species known to support SATS infection tolerate many amino acid changes, indicating that the species barrier might be low.