S
Shuofeng Yuan
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 130
Citations - 18103
Shuofeng Yuan is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 30, co-authored 85 publications receiving 12727 citations. Previous affiliations of Shuofeng Yuan include University of Hong Kong.
Papers
More filters
Journal ArticleDOI
A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.
Jasper Fuk-Woo Chan,Shuofeng Yuan,Kin-Hang Kok,Kelvin K. W. To,Kelvin K. W. To,Hin Chu,Jin Yang,Fanfan Xing,Jieling Liu,Cyril C. Y. Yip,Rosana W.S. Poon,Hoi Wah Tsoi,Simon Kam Fai Lo,Kwok-Hung Chan,Vincent Kwok-Man Poon,Wan Mui Chan,Jonathan Daniel Ip,Jian Piao Cai,Vincent C.C. Cheng,Honglin Chen,Honglin Chen,Christopher K.M. Hui,Kwok-Yung Yuen +22 more
TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
Journal ArticleDOI
Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan.
Jasper Fuk-Woo Chan,Kin-Hang Kok,Kin-Hang Kok,Zheng Zhu,Hin Chu,Hin Chu,Kelvin K. W. To,Shuofeng Yuan,Shuofeng Yuan,Kwok-Yung Yuen +9 more
TL;DR: Binformatics analysis on a virus genome from a patient with 2019-nCoV infection and compared it with other related coronavirus genomes provide the basis for starting further studies on the pathogenesis, and optimizing the design of diagnostic, antiviral and vaccination strategies for this emerging infection.
Journal ArticleDOI
Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility.
Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Anna Jinxia Zhang,Shuofeng Yuan,Vincent Kwok-Man Poon,Chris Chung-Sing Chan,Andrew Chak-Yiu Lee,Wan Mui Chan,Zhimeng Fan,Hoi Wah Tsoi,Lei Wen,Ronghui Liang,Jianli Cao,Yanxia Chen,Kaiming Tang,Cuiting Luo,Jian Piao Cai,Kin-Hang Kok,Hin Chu,Kwok-Hung Chan,Siddharth Sridhar,Siddharth Sridhar,Siddharth Sridhar,Zhiwei Chen,Honglin Chen,Kelvin K. W. To,Kelvin K. W. To,Kelvin K. W. To,Kwok-Yung Yuen,Kwok-Yung Yuen,Kwok-Yung Yuen +31 more
TL;DR: Besides satisfying the Koch’s postulates, this readily available hamster model is an important tool for studying transmission, pathogenesis, treatment, and vaccination against SARS-CoV-2.
Journal ArticleDOI
Coronavirus Disease 2019 (COVID-19) Re-infection by a Phylogenetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 Strain Confirmed by Whole Genome Sequencing.
Kelvin K. W. To,Kelvin K. W. To,Ivan Hung,Jonathan Daniel Ip,Allen Wing-Ho Chu,Wan-Mui Chan,Anthony Raymond Tam,Carol Ho-Yan Fong,Shuofeng Yuan,Hoi-Wah Tsoi,Anthony Chin-Ki Ng,Larry Lap-Yip Lee,Polk Wan,Eugene Yuk-Keung Tso,Wing-Kin To,Dominic N.C. Tsang,Kwok-Hung Chan,Jian-Dong Huang,Kin-Hang Kok,Vincent C.C. Cheng,Vincent C.C. Cheng,Kwok-Yung Yuen,Kwok-Yung Yuen +22 more
TL;DR: The results suggest SARS-CoV-2 may continue to circulate among the human populations despite herd immunity due to natural infection or vaccination, and further studies of patients with re-infection will shed light on protective correlates important for vaccine design.
Journal ArticleDOI
Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study.
Hin Chu,Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Terrence Tsz-Tai Yuen,Huiping Shuai,Shuofeng Yuan,Yixin Wang,Bingjie Hu,Cyril C. Y. Yip,Jessica Oi-Ling Tsang,Xiner Huang,Yue Chai,Dong Yang,Yuxin Hou,Kenn Ka-Heng Chik,Xi Zhang,Agnes Yim Fong Fung,Hoi-Wah Tsoi,Jian-Piao Cai,Wan-Mui Chan,Jonathan Daniel Ip,Allen Wing-Ho Chu,Jie Zhou,David Christopher Lung,Kin-Hang Kok,Kelvin K. W. To,Kelvin K. W. To,Owen Tak-Yin Tsang,Kwok-Hung Chan,Kwok-Yung Yuen +29 more
TL;DR: This study presents the first quantitative data for tropism, replication kinetics, and cell damage of SARS-CoV-2, and provides novel insights into the lower incidence of diarrhoea, decreased disease severity, and reduced mortality in patients with COVID-19.