Shuxin Sun

TL;DR: The alteration of CD8+ T cell between D3 and D7 showed relatively good performance and could be used as an effective tool for prognostic evaluation for LAPC patients after IRE, the first evidence of IRE-based immunomodulatory in patients with LapC.

TL;DR: Oxidative stress in the tumor microenvironment could induce MMT in PDAC, thus inducing reactive stroma, modulating immunosuppression, and promoting tumor progression, and reducing oxidative stress may be a promising future therapeutic regimen.

TL;DR: Induction chemotherapy followed by IRE is superior to induction chemotherapy following by radiotherapy for treating LAPC and a randomized clinical trial comparing the efficacy of IRE and radiotherapy after the induction chemotherapy is considerable.

TL;DR: In this paper, reversible electroporation was used to induce macrophage polarization induced by activating the MAPK-p38 pathway and increasing the expression of M1 markers in macrophages, through binding to the advanced glycation endproduct (RAGE) receptor.

TL;DR: It was shown that IRE triggered reactive oxygen species (ROS)-dependent apoptosis in pancreatic cancer cells (PCCs) mediated by phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway suppression and when NanoKnife was combined with M1 virus, the therapeutic efficacy was synergistically enhanced.