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Shuyang Xu
Researcher at Guangzhou Institutes of Biomedicine and Health
Publications - 7
Citations - 182
Shuyang Xu is an academic researcher from Guangzhou Institutes of Biomedicine and Health. The author has contributed to research in topics: Reprogramming & Chromatin. The author has an hindex of 4, co-authored 7 publications receiving 64 citations.
Papers
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Journal ArticleDOI
Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE.
Jiangping He,Isaac A. Babarinde,Li Sun,Shuyang Xu,Ruhai Chen,Junjie Shi,Yuanjie Wei,Yuhao Li,Gang Ma,Qiang Zhuang,Andrew P. Hutchins,Jiekai Chen +11 more
TL;DR: In this article, a single-cell transposable element (TE) processing pipeline, scTE, was developed to report the expression of TEs in single cells in a range of biological contexts.
Journal ArticleDOI
SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States
Kaixin Wu,He Liu,Yaofeng Wang,Jiangping He,Shuyang Xu,Yaping Chen,Yaping Chen,Junqi Kuang,Junqi Kuang,Jiadong Liu,Jiadong Liu,Lin Guo,Dongwei Li,Ruona Shi,Li Shen,Yangming Wang,Xiaofei Zhang,Jie Wang,Duanqing Pei,Jiekai Chen +19 more
TL;DR: Under the "ground state" of pluripotency with two inhibitors (2i) of the MEK and GSK3 pathways, Setdb1-knockout fails to induce trophectoderm differentiation as in serum/LIF (SL), indicating that TE fate restriction is not the direct target of SETDB1.
Journal ArticleDOI
YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.
Jiadong Liu,Jiadong Liu,Mingwei Gao,Mingwei Gao,Shuyang Xu,Yaping Chen,Yaping Chen,Kaixin Wu,He Liu,Jie Wang,Xuejie Yang,Junwei Wang,Weiwei Liu,Xichen Bao,Jiekai Chen +14 more
TL;DR: Overall, YTHDF2/3 couples RNA deadenylation and regulation with the clearance of somatic genes and provides insights into iPSC reprogramming at the posttranscriptional level.
Journal ArticleDOI
BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling.
Shengyong Yu,Chunhua Zhou,Shangtao Cao,Shangtao Cao,Jiangping He,Baomei Cai,Kaixin Wu,Kaixin Wu,Yue Qin,Xingnan Huang,Xingnan Huang,Lizhan Xiao,Lizhan Xiao,Jing Ye,Jing Ye,Shuyang Xu,Wenxiu Xie,Wenxiu Xie,Junqi Kuang,Shilong Chu,Shilong Chu,Jing Guo,Jing Guo,He Liu,He Liu,Wei Pang,Wei Pang,Lin Guo,Lin Guo,Mengying Zeng,Mengying Zeng,Xiaoshan Wang,Rongping Luo,Rongping Luo,Chen Li,Chen Li,Guoqing Zhao,Bo Wang,Bo Wang,Linlin Wu,Linlin Wu,Jiekai Chen,Jing Liu,Duanqing Pei +43 more
TL;DR: A previously unknown function of BMP4 in regulating nuclear architecture is revealed and its targets ZBTB7A/B are linked to chromatin remodelling and pluripotent fate control.
Journal ArticleDOI
SS18 regulates pluripotent-somatic transition through phase separation.
Junqi Kuang,Junqi Kuang,Ziwei Zhai,Ziwei Zhai,Pengli Li,Pengli Li,Ruona Shi,Ruona Shi,Wenjing Guo,Yuxiang Yao,Jing Guo,Guoqing Zhao,Jiangpin He,Shuyang Xu,Chuman Wu,Shengyong Yu,Shengyong Yu,Chunhua Zhou,Chunhua Zhou,Linlin Wu,Yue Qin,Yue Qin,Baomei Cai,Wei Li,Wei Li,Zichao Wu,Zichao Wu,Xiaoxi Li,Xiaoxi Li,Shilong Chu,Tingting Yang,Tingting Yang,Bo Wang,Shangtao Cao,Dongwei Li,Xiaofei Zhang,Jiekai Chen,Jing Liu,Duanqing Pei +38 more
TL;DR: In this paper, the authors identify a requirement for SS18-mediated Brg/Brahma-associated factors (BAF) chromatin remodeling complex assembly during exit from pluripotency, and that SS18 promotes BAF assembly through liquid-liquid phase separation.