S
Shuzhen Hong
Researcher at Agency for Science, Technology and Research
Publications - 14
Citations - 1686
Shuzhen Hong is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Promoter & Gene. The author has an hindex of 11, co-authored 14 publications receiving 1553 citations. Previous affiliations of Shuzhen Hong include University of Pittsburgh & Genome Institute of Singapore.
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Journal ArticleDOI
Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation.
Guoliang Li,Xiaoan Ruan,Raymond K. Auerbach,Kuljeet Singh Sandhu,Meizhen Zheng,Ping Wang,Huay Mei Poh,Yufen Goh,Joanne Lim,Jingyao Zhang,Hui Shan Sim,Su Qin Peh,Fabianus Hendriyan Mulawadi,Chin Thing Ong,Yuriy L. Orlov,Shuzhen Hong,Zhizhuo Zhang,Steve Landt,Debasish Raha,Ghia Euskirchen,Chia-Lin Wei,Weihong Ge,Huaien Wang,Carrie A. Davis,Katherine I. Fisher-Aylor,Ali Mortazavi,Mark Gerstein,Thomas R. Gingeras,Barbara J. Wold,Yi Sun,Melissa J. Fullwood,Edwin Cheung,Edwin Cheung,Edison T. Liu,Wing-Kin Sung,Wing-Kin Sung,Michael Snyder,Yijun Ruan,Yijun Ruan +38 more
TL;DR: In conclusion, this study provides insights into transcription regulation by three-dimensional chromatin interactions for both housekeeping and cell-specific genes in human cells through widespread promoter-centered intragenic, extragenics, and intergenic interactions.
Journal ArticleDOI
A transcriptional repressor co‐regulatory network governing androgen response in prostate cancers
Kern Rei Chng,Kern Rei Chng,Cheng Wei Chang,Cheng Wei Chang,Si Kee Tan,Si Kee Tan,Chong Yang,Chong Yang,Shuzhen Hong,Noel Yan Wei Sng,Edwin Cheung +10 more
TL;DR: In this article, the Androgen receptor (AR) and its corepressors are used to suppress Vinculin expression in prostate cancer cells, which leads to enhanced invasiveness.
Regulation of Estrogen Receptor-mediated Long Range Transcription via Evolutionarily Conserved Distal
You Fu Pan,Mei Hui Liu,Bing Zhao,Shuzhen Hong,Peck Yean Tan,Kar Sian Lim,Guillaume Bourque,Edison T. Liu,Edwin Cheung +8 more
TL;DR: In this article, the authors examined whether ER binding sites that are located distal from the transcription start sites of estrogen target genes are functionally relevant and found that ERs occupied at the distal sites are capable of communicating with ERs bound at the proximal promoter region, possibly via long range chromosome looping.
Journal ArticleDOI
Regulation of Estrogen Receptor-mediated Long Range Transcription via Evolutionarily Conserved Distal Response Elements
You Fu Pan,K. D. Senali Abayratna Wansa,Mei Hui Liu,Bing Zhao,Shuzhen Hong,Peck Yean Tan,Kar Sian Lim,Guillaume Bourque,Edison T. Liu,Edwin Cheung,Edwin Cheung,Edwin Cheung +11 more
TL;DR: The data indicate that distal ER binding sites are bona fide transcriptional enhancers that are involved in long range chromosomal interaction, transcription complex formation, and distinct structural modifications of chromatin across large genomic spans.
Journal ArticleDOI
BAsE-Seq: a method for obtaining long viral haplotypes from short sequence reads
Lewis Z. Hong,Lewis Z. Hong,Shuzhen Hong,Han Teng Wong,Pauline P. K. Aw,Yan Cheng,Andreas Wilm,Paola Florez de Sessions,Seng Gee Lim,Seng Gee Lim,Niranjan Nagarajan,Martin L. Hibberd,Martin L. Hibberd,Stephen R. Quake,Stephen R. Quake,William F. Burkholder +15 more
TL;DR: Applying BAsE-Seq to a clinical sample, over 9,000 viral haplotypes were obtained, which provided an unprecedented view of hepatitis B virus population structure during chronic infection and is readily applicable for monitoring quasispecies evolution in viruses.