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Shweta Jaiswal

Bio: Shweta Jaiswal is an academic researcher from Maharshi Dayanand University. The author has contributed to research in topics: Medicine & Bioremediation. The author has an hindex of 6, co-authored 7 publications receiving 305 citations.

Papers
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Journal ArticleDOI
TL;DR: The present review focuses on the environmental sources of antibiotics, it's possible degradation mechanisms, health effects, and bacterial antibiotics resistance mechanisms, and the antibiotic degradation and elimination from the environment and its health benefits.

327 citations

Journal ArticleDOI
TL;DR: The present review deciphers the bio-degradation network, i.e., the databases and datasets aiding in assisting the degradation and deterioration potential of microorganisms for bioremediation processes, computational biology and multi omics approaches like metagenomics, genomics, transcriptomics, proteomics, and metabolomics for the efficient functional gene mining and their validation for biOREmediation experiments.
Abstract: Bioremediation is the degradation potential of microorganisms to dissimilate the complex chemical compounds from the surrounding environment. The genetics and biochemistry of biodegradation processes in datasets opened the way of systems biology. Systemic biology aid the study of interacting parts involved in the system. The significant keys of system biology are biodegradation network, computational biology, and omics approaches. Biodegradation network consists of all the databases and datasets which aid in assisting the degradation and deterioration potential of microorganisms for bioremediation processes. This review deciphers the bio-degradation network, i.e., the databases and datasets (UM-BBD, PAN, PTID, etc.) aiding in assisting the degradation and deterioration potential of microorganisms for bioremediation processes, computational biology and multi omics approaches like metagenomics, genomics, transcriptomics, proteomics, and metabolomics for the efficient functional gene mining and their validation for bioremediation experiments. Besides, the present review also describes the gene editing tools like CRISPR Cas, TALEN, and ZFNs which can possibly make design microbe with functional gene of interest for degradation of particular recalcitrant for improved bioremediation.

122 citations

Journal ArticleDOI
TL;DR: Recent biotechnological approaches, including synthetic microbial consortia, systems biology tools, and genetic engineering techniques which can pave the path towards the plastic bioremediation and degradation are recapitulated.
Abstract: The present state of constantly increasing plastic pollution is the major concern of scientific researchers. The conventional techniques applied (i.e., burning and landfilling) to get plastic degraded from the environment are inadequate due to harmful byproducts and limited to its recycling. In this review, we have recapitulated recent biotechnological approaches, including synthetic microbial consortia, systems biology tools, and genetic engineering techniques which can pave the path towards the plastic bioremediation and degradation. Moreover, potential plastic degrader microbes and their degradation pathways are also summarized. Lastly, this review focuses on enhancing the understanding of the degradation ability of microorganisms using contemporary biotechnological tools.

93 citations

Journal ArticleDOI
TL;DR: Cell coordination in synthetic microbial community, cell signaling, and quorum sensing as engineered for enhanced bioremediation strategies are described, along with promising gene editing tools for obtaining the host with target gene sequences responsible for the degradation of recalcitrant compounds.
Abstract: Continuous contamination of the environment with xenobiotics and related recalcitrant compounds has emerged as a serious pollution threat. Bioremediation is the key to eliminating persistent contaminants from the environment. Traditional bioremediation processes show limitations, therefore it is necessary to discover new bioremediation technologies for better results. In this review we provide an outlook of alternative strategies for bioremediation via synthetic biology, including exploring the prerequisites for analysis of research data for developing synthetic biological models of microbial bioremediation. Moreover, cell coordination in synthetic microbial community, cell signaling, and quorum sensing as engineered for enhanced bioremediation strategies are described, along with promising gene editing tools for obtaining the host with target gene sequences responsible for the degradation of recalcitrant compounds. The synthetic genetic circuit and two-component regulatory system (TCRS)-based microbial biosensors for detection and bioremediation are also briefly explained. These developments are expected to increase the efficiency of bioremediation strategies for best results.

80 citations

Journal Article
TL;DR: The study revealed significant genotypes x environment interaction for both kernel Fe and Zn concentration, of which kernel Fe was found to be affected more by the change of environmental conditions, while it was of less extent for kernel Zn.
Abstract: Evaluation of kernel iron (Fe) and zinc (Zn) of 67 diverse maize genotypes grown during 2006–08 indicated significant variation for both the micronutrients. Kernel Fe concentration during 2006 varied from 20.38–43.79 mg/kg, whereas the same ranged from 23.23–54.29 mg/kg and 29.22–49.24 mg/kg, during 2007 and 2008, respectively. Kernel Zn varied from 15.06–29.88 mg/kg, 7.01–22.01 mg/kg and 13.64–26.54 mg/kg, during 2006, 2007 and 2008, respectively. No correlation was observed between kernel Fe and Zn concentration in the selected set of maize genotypes. For Fe concentration, CM140 (43.79 mg/kg) was found to be the most promising genotype during 2006, with HP-3 (54.29 mg/kg) during 2007 and CM212 (49.24 mg/kg) during 2008 as the best genotype. In case of kernel Zn, BAJIM-06-6 (29.88 mg/kg), V336 (22.01 mg/kg) and BAJIM-06-10 (26.45 mg/kg) were identified to be the best genotype in 2006, 2007 and 2008, respectively. The study revealed significant genotypes x environment interaction for both kernel Fe and Zn concentration, of which kernel Fe was found to be affected more by the change of environmental conditions, while it was of less extent for kernel Zn.Taking into consideration of stability parameters V336,VQL5, CM139,VQL1, CM129, and V340 were observed to be stable and promising genotypes for kernel Fe concentration, while in case of kernel Zn,V336, BAJIM-0610,V340, BAJIM-06-7, CM129, and VQL1 were identified as the stable genotypes.

23 citations


Cited by
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01 Jan 2020
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Abstract: Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

4,408 citations

Journal ArticleDOI
TL;DR: The risk data indicate that selected antibiotics may pose a threat to aquatic environments, and Cyanobacteria were the most sensitive organisms when using standard ecotoxicological bioassays.

582 citations

Journal ArticleDOI
TL;DR: Tolerance and response of different microalgae strains to heavy metals and their bioaccumulation capability with value-added by-products formation as well as utilization of non-living biomass as biosorbents are discussed.

389 citations

Journal ArticleDOI
TL;DR: Among different Pb-remediation approaches, certain advanced approaches such as microbial assisted phytoremediation which could possibly minimize the Pb load from the resources in a sustainable manner and would be a viable option to ensure a safe food production system are highlighted.
Abstract: Lead (Pb) toxicity has been a subject of interest for environmental scientists due to its toxic effect on plants, animals, and humans. An increase in several Pb related industrial activities and use of Pb containing products such as agrochemicals, oil and paint, mining, etc. can lead to Pb contamination in the environment and thereby, can enter the food chain. Being one of the most toxic heavy metals, Pb ingestion via the food chain has proven to be a potential health hazard for plants and humans. The current review aims to summarize the research updates on Pb toxicity and its effects on plants, soil, and human health. Relevant literature from the past 20 years encompassing comprehensive details on Pb toxicity has been considered with key issues such as i) Pb bioavailability in soil, ii) Pb biomagnification, and iii) Pb- remediation, which has been addressed in detail through physical, chemical, and biological lenses. In the review, among different Pb-remediation approaches, we have highlighted certain advanced approaches such as microbial assisted phytoremediation which could possibly minimize the Pb load from the resources in a sustainable manner and would be a viable option to ensure a safe food production system.

351 citations

Journal ArticleDOI
TL;DR: In this paper , the advantages and challenges of bioplastics in transitioning towards a circular economy are assessed. But these benefits can have trade-offs, including negative agricultural impacts, competition with food production, unclear EOL management and higher costs.
Abstract: Bioplastics - typically plastics manufactured from bio-based polymers - stand to contribute to more sustainable commercial plastic life cycles as part of a circular economy, in which virgin polymers are made from renewable or recycled raw materials. Carbon-neutral energy is used for production and products are reused or recycled at their end of life (EOL). In this Review, we assess the advantages and challenges of bioplastics in transitioning towards a circular economy. Compared with fossil-based plastics, bio-based plastics can have a lower carbon footprint and exhibit advantageous materials properties; moreover, they can be compatible with existing recycling streams and some offer biodegradation as an EOL scenario if performed in controlled or predictable environments. However, these benefits can have trade-offs, including negative agricultural impacts, competition with food production, unclear EOL management and higher costs. Emerging chemical and biological methods can enable the 'upcycling' of increasing volumes of heterogeneous plastic and bioplastic waste into higher-quality materials. To guide converters and consumers in their purchasing choices, existing (bio)plastic identification standards and life cycle assessment guidelines need revision and homogenization. Furthermore, clear regulation and financial incentives remain essential to scale from niche polymers to large-scale bioplastic market applications with truly sustainable impact.

283 citations