S
Siarhei Hladyshau
Researcher at Georgia Institute of Technology
Publications - 9
Citations - 35
Siarhei Hladyshau is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Biology & GTPase. The author has an hindex of 2, co-authored 4 publications receiving 20 citations.
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Journal ArticleDOI
Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity.
TL;DR: It is reported that spatiotemporal enrichment of actin monomers (G-actin) in dendritic spines regulates spine development and plasticity and reveals a novel mechanism by which dynamic enrichment of G-actins regulates the actin remodeling underlying synapse development and Plasticity.
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Biomechanics of Endothelial Tubule Formation Differentially Modulated by Cerebral Cavernous Malformation Proteins.
Olga Chernaya,Anastasia Zhurikhina,Siarhei Hladyshau,William Pilcher,Katherine M. Young,Jillian Ortner,Vaishnavi Andra,Todd Sulchek,Denis Tsygankov +8 more
TL;DR: This work uses a comprehensive simulation model to dissect the mechanisms contributing to an emergent behavior of the multicellular system and gains a systems-level understanding of the basic mechanisms of vascular tubule formation, its destabilization, and pharmacological rescue.
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Spatiotemporal development of coexisting wave domains of Rho activity in the cell cortex
TL;DR: An automated method of wave domain detection is developed, which revealed a sharp reversal of pattern formation in the middle of anaphase in starfish oocytes, providing an insight into spatiotemporal regulation of complex and diverse but still computationally reproducible cell-level actin dynamics.
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Bistability in the polarity circuit of yeast
TL;DR: In this article, the authors used microfluidics to precisely control the temporal profile of mating pheromone and live-cell imaging to monitor the polarity process in single living cells.
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Spatiotemporal Coordination of Rac1 and Cdc42 at the Whole Cell Level during Cell Ruffling
TL;DR: In this article , the authors investigate the temporal and spatial relationship between Rac1 and Cdc42 during membrane ruffling using a simulation model which couples GTPase signaling with cell morphodynamics.