S
Sibdas Ghosh
Researcher at German Cancer Research Center
Publications - 10
Citations - 99
Sibdas Ghosh is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Mitosis & Anaphase. The author has an hindex of 5, co-authored 10 publications receiving 99 citations.
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Journal ArticleDOI
Okadaic Acid Overrides the S-Phase Check Point and Accelerates Progression of G2-Phase to Induce Premature Mitosis in HeLa Cells
TL;DR: It has been argued that OA may modulate both a tyrosine kinase and a tyosine phosphatase activity to override the S-phase checkpoint and accelerate the activation of MPF in cells in G2-phase, respectively.
Journal Article
Effects of okadaic acid on mitotic HeLa cells.
TL;DR: The role of phosphatase 1 in controlling some late mitotic events, i.e. sister chromatid separation, MPF-inactivation and nuclear envelope re-formation etc., is discussed.
Journal Article
Effects of low concentrations of okadaic acid in HeLa cells.
TL;DR: HeLa cells treated for prolonged period with okadaic acid inhibiting protein phosphatase 2A (PP2A) and also proteinosphatase 1 (PP1) partially showed prolonged effects on mitotic progression and the cyclin degradation at the metaphase-anaphase transition have been discussed.
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Failure of centromere separation leads to formation of diplochromosomes in next mitosis in okadaic acid treated HeLa cells
TL;DR: It has been demonstrated that the sister chromatid adherence does not depend on any under‐replicated chromatin segment shared by the sister Chromatids which might happen in okadaic acid induced premature mitosis, but due to the failure of the centromeres to separate at metaphase ‐ anaphase transition.
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Microtubule rearrangements during mitosis in multinucleate cells.
TL;DR: It is demonstrated here that the transition of the microtubular cytoskeleton from interphase to mitosis is an inducible event and independent of the factor(s) responsible for chromatin condensation and nuclear envelope breakdown.