Sibylle Schneider-Schaulies

TL;DR: The unique property of MV wild-type strains to activate TLR2-dependent signals might essentially contribute not only to immune activation but also to viral spread and pathogenicity by upregulating the MV receptor on monocytes.

TL;DR: Data indicate that the differentiation of effector functions of DCs is not impaired but rather is stimulated by MV infection, and that mature, activated DCs expressing MV surface antigens do give a negative signal to inhibit lymphocyte proliferation and thus contribute to MV-induced immunosuppression.

TL;DR: The data indicate that proliferation inhibition induced by MV contact is independent of the presence or absence of the virus-binding receptors SLAM and CD46, and the cell-type-specific expression of SLAM does not correlate with the sensitivity of cells for proliferation inhibition.

TL;DR: It is indicated that a small number of MV-infected PBLs can induce a general nonresponsiveness in uninfected P BLs by surface contact, which may, in turn, account for the general suppression of immune responses observed in patients with acute measles.

TL;DR: The results demonstrate that the antiviral spectrum of MxA is not restricted to negative-strand RNA viruses but also includes SFV, which contains an RNA genome of positive polarity.