S
Sidney M. Morris
Researcher at University of Pittsburgh
Publications - 122
Citations - 16157
Sidney M. Morris is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Arginase & Arginine. The author has an hindex of 57, co-authored 122 publications receiving 15129 citations. Previous affiliations of Sidney M. Morris include National Institutes of Health & Baylor College of Medicine.
Papers
More filters
Journal ArticleDOI
Arginine metabolism : nitric oxide and beyond
Guoyao Wu,Sidney M. Morris +1 more
TL;DR: Physiological roles and relationships between the pathways of arginine synthesis and catabolism in vivo are complex and difficult to analyse, owing to compartmentalized expression of various enzymes at both organ and subcellular levels.
Journal ArticleDOI
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
Claudia R. Morris,Gregory J. Kato,Mirjana Poljakovic,Xunde Wang,William C. Blackwelder,Vandana Sachdev,Stanley L. Hazen,Elliott Vichinsky,Sidney M. Morris,Mark T. Gladwin +9 more
TL;DR: These data support a novel mechanism of disease in which hemolysis contributes to reduced nitric oxide bioavailability and endothelial dysfunction via release of erythrocyte arginase, which limits arginine bioavailability, and release of ______ hemoglobin, which scavengesNitric oxide.
Journal ArticleDOI
Regulation of enzymes of the urea cycle and arginine metabolism
TL;DR: This review emphasizes recent information regarding roles and regulation of urea cycle and arginine metabolic enzymes in liver and other cell types.
Journal ArticleDOI
New insights into the regulation of inducible nitric oxide synthesis
TL;DR: The roles NO plays in sepsis and the potential impact of arginine metabolism on NO synthesis are discussed and the only physiological nitrogen donor for NO synthesis, metabolism of this amino acid may play an important role in regulation of NO synthesis during sepsi.
Journal ArticleDOI
Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
Gregory J. Kato,Gregory J. Kato,Gregory J. Kato,Vicki R. McGowan,Vicki R. McGowan,Vicki R. McGowan,Roberto F. Machado,Roberto F. Machado,Roberto F. Machado,Jane A. Little,Jane A. Little,Jane A. Little,James G. Taylor Vi,James G. Taylor Vi,James G. Taylor Vi,Claudia R Morris,Claudia R Morris,Claudia R Morris,James S. Nichols,James S. Nichols,James S. Nichols,Xunde Wang,Xunde Wang,Xunde Wang,Mirjana Poljakovic,Mirjana Poljakovic,Mirjana Poljakovic,Sidney M. Morris,Sidney M. Morris,Sidney M. Morris,Mark T. Gladwin,Mark T. Gladwin,Mark T. Gladwin +32 more
TL;DR: It is proposed that LDH elevation identifies patients with a syndrome of hemolysis-associated NO resistance, endothelial dysfunction, and end-organ vasculopathy, as well as a clinical subphenotype of pulmonary hypertension, leg ulceration, priapism, and risk of death in patients with sickle cell disease.