S
Sidney Pestka
Researcher at University of Medicine and Dentistry of New Jersey
Publications - 310
Citations - 19218
Sidney Pestka is an academic researcher from University of Medicine and Dentistry of New Jersey. The author has contributed to research in topics: Interferon & Receptor. The author has an hindex of 71, co-authored 310 publications receiving 18710 citations. Previous affiliations of Sidney Pestka include Rutgers University & Columbia University.
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Journal ArticleDOI
Interleukin-10 and Related Cytokines and Receptors
Sidney Pestka,Christopher D. Krause,Devanand Sarkar,Mark R. Walter,Yufang Shi,Paul B. Fisher +5 more
TL;DR: These cytokines have significant roles in a variety of pathophysiological processes as well as in regulation of the immune system and further investigation of these critical intercellular signaling molecules will provide important information to enable these proteins to be used more extensively in therapy for a range of diseases.
Journal Article
Biological Properties of Recombinant α-Interferons: 40th Anniversary of the Discovery of Interferons
Lawrence M. Pfeffer,Charles A. Dinarello,Ronald B. Herberman,Bryan R.G. Williams,Ernest C. Borden,Ronald Bordens,Mark R. Walter,Tattanahalli L. Nagabhushan,Paul P. Trotta,Sidney Pestka +9 more
TL;DR: Recent developments in the understanding of the antiviral and immunoregulatory properties of IFN-alpha, the nature of the multisubunit IFn-alpha receptor, and the molecular mechanisms of signal transduction are reviewed.
Journal ArticleDOI
Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)
TL;DR: In this paper, the authors identified a viral IL-10 homolog encoded by an ORF (UL111a) within the human cytomegalovirus (CMV) genome, which they designated cmvIL-10.
Journal ArticleDOI
Identification of the Functional Interleukin-22 (IL-22) Receptor Complex THE IL-10R2 CHAIN (IL-10Rβ) IS A COMMON CHAIN OF BOTH THE IL-10 AND IL-22 (IL-10-RELATED T CELL-DERIVED INDUCIBLE FACTOR, IL-TIF) RECEPTOR COMPLEXES
Sergei V. Kotenko,Lara S. Izotova,Olga V. Mirochnitchenko,Elena Esterova,Harold Dickensheets,Raymond P. Donnelly,Sidney Pestka +6 more
TL;DR: Sharing of the common IL-10R2 chain between the IL- 10 and IL-TIF receptor complexes is the first such case for receptor complexes with chains belonging to the class II cytokine receptor family, establishing a novel paradigm for IL-9-related ligands similar to the shared use of the gamma common chain by several cytokines.
Journal ArticleDOI
Identification and functional characterization of a second chain of the interleukin-10 receptor complex.
Serguei V. Kotenko,Christopher D. Krause,Lara S. Izotova,Brian P. Pollack,Wei Wu,Sidney Pestka +5 more
TL;DR: The CRFB4 chain, which is designated as the IL‐10R2 or IL‐ 10Rβ chain, serves as an accessory chain essential for the activeIL‐10 receptor complex and to initiate IL‐8‐induced signal transduction events.