Sidney Teitel

Bio: Sidney Teitel is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Tetrahydroisoquinoline & Methylenedioxy. The author has an hindex of 19, co-authored 78 publications receiving 930 citations.

A new antibiotic x-5108 of streptomyces origin i. production, isolation and properties

Abstract: A new antibiotic, designated X-5108, produced by a new species of microorganism named Streptomyces goldiniensis var. goldiniensis, has been isolated in essentially pure but amorphous form. Assay methods, and cultivation and isolation procedures for the antibiotic are described. The antibiotic is active in vitro primarily against a number of gram-positive bacteria, whereas in vivo it is especially active against Streptococcus pyogenes infections of mice and as a poultry growth promotant. It shows a very low toxicity in mice with an LD50 of >lg/kg sbc, and >4 g/kg p.o. Its empirical formula is C44H62N2O12. Structural studies reveal one methoxyl, one N-methyl and six C-methyl groups. UV, IR and NMR spectra and optical rotation of the pure antibiotic are given. The antibiotic appears to belong to a new chemical class.

Alkaloids' in mammalian tissues. I. Condensation of L-dopa and its two mono-O-methyl ethers with formaldehyde and acetaldehyde.

Abstract: In der Annahme, dass gewisse Aminosauren im Gewebe von Saugetieren Vorlaufer fur «alkaloidische» Tetrahydro-isochinoline sein konnten, wurden L-Dopa und dessen zwei Monomethylather mit Formaldehyd und Acetaldehyd kondensiert. Die absolute Stereochemie der erhaltenen 1-Methyl-substituierten Tetrahydro-isochinoline wurde durch Rontgen-Analyse einer Schlusselverbindung sichergestellt.

(R-(R*R*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl-3-phenyl-4((phenylamino)-carbonyl)-1H-pyrrole-1-heptanoic acid, its lactone form and salts thereof

Abstract: [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-((1-­methylethyl)-3-phenyl-4-[(phenylamino)-carbonyl]-1H-­pyrrole-1-heptanoic acid or (2R-trans)-5-(4-fluorophenyl)-­2-(1-methylethyl-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-­oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide; a process for their preparation and pharmaceutically acceptable salts thereof.

Base Specificity in the Interaction of Polynucleotides with Antibiotic Drugs

Abstract: Echinomycin, daunomycin, ethidium bromide, nogalamycin, chromomycin, mithramycin, and olivomycin inhibit RNA synthesis by RNA polymerase by interacting with the DNA template. Chromomycin and olivomycin form complexes with DNA, preferably in the helical form, but not with RNA. These complexes require guanine in DNA and the addition of a stoichiometric amount of bivalent cation. None of the other antibiotics requires the presence of any single base in the template for its action.