다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

Recent advances in mechanics and materials provide routes to integrated circuits that can offer the electrical properties of conventional, rigid wafer-based technologies but with the ability to be stretched, compressed, twisted, bent, and deformed into arbitrary shapes. Inorganic and organic electronic materials in microstructured and nanostructured forms, intimately integrated with elastomeric substrates, offer particularly attractive characteristics, with realistic pathways to sophisticated embodiments. Here, we review these strategies and describe applications of them in systems ranging from electronic eyeball cameras to deformable light-emitting displays. We conclude with some perspectives on routes to commercialization, new device opportunities, and remaining challenges for research.

http://science.sciencemag.org/content/sci/327/5973/1603.full.pdf

Materials and mechanics for stretchable electronics

Microfabricated integrated circuits revolutionized computation by vastly reducing the space, labor, and time required for calculations. Microfluidic systems hold similar promise for the large-scale automation of chemistry and biology, suggesting the possibility of numerous experiments performed rapidly and in parallel, while consuming little reagent. While it is too early to tell whether such a vision will be realized, significant progress has been achieved, and various applications of significant scientific and practical interest have been developed. Here a review of the physics of small volumes (nanoliters) of fluids is presented, as parametrized by a series of dimensionless numbers expressing the relative importance of various physical phenomena. Specifically, this review explores the Reynolds number Re, addressing inertial effects; the Peclet number Pe, which concerns convective and diffusive transport; the capillary number Ca expressing the importance of interfacial tension; the Deborah, Weissenberg, and elasticity numbers De, Wi, and El, describing elastic effects due to deformable microstructural elements like polymers; the Grashof and Rayleigh numbers Gr and Ra, describing density-driven flows; and the Knudsen number, describing the importance of noncontinuum molecular effects. Furthermore, the long-range nature of viscous flows and the small device dimensions inherent in microfluidics mean that the influence of boundaries is typically significant. A variety of strategies have been developed to manipulate fluids by exploiting boundary effects; among these are electrokinetic effects, acoustic streaming, and fluid-structure interactions. The goal is to describe the physics behind the rich variety of fluid phenomena occurring on the nanoliter scale using simple scaling arguments, with the hopes of developing an intuitive sense for this occasionally counterintuitive world.

/pdf/microfluidics-fluid-physics-at-the-nanoliter-scale-4bpahtd8qa.pdf

Microfluidics: Fluid physics at the nanoliter scale

Stripes of thin gold films are made on an elastomeric substrate with built-in compressive stress to form surface waves. Because these waves can be stretched flat they function as elastic electrical conductors. Surprisingly, we observe electrical continuity not only up to an external strain of ∼2% reached by stretching the films first flat (∼0.4%) and then to the fracture strain of free-standing gold films (∼1%), but up to ∼22%. Such large strains will permit making stretchable electric conductors that will be essential to three-dimensional electronic circuits.

Stretchable gold conductors on elastomeric substrates

The mechanics of film-on-foil devices is presented in the context of thin-film transistors on steel and plastic foils Provided the substrates are thin, such transistors function well after the foils are rolled to small radii of curvature When a substrate with a lower elastic modulus is used, smaller radii of curvature can be achieved Furthermore, when the transistors are placed in the neutral surface by sandwiching between a substrate and an encapsulation layer, even smaller radii of curvature can be attained Transistor failure clearly shows when externally forced and thermally induced strains add to, or subtract from, each other

Mechanics of rollable and foldable film-on-foil electronics

Elastic electronic surfaces will integrate stiff thin film devices onto compliant polymer substrates. These surfaces may be stretched once or many times, by up to tens of percent strain. One way to make such an elastic electronic surface is to distribute rigid subcircuit islands over the polymer surface, and then fabricate active devices on the islands. These islands need to be interconnected with stretchable metallization. We describe stretchable interconnects made of stripes of thin gold film patterned on elastomeric membranes. These membranes can be stretched by up to twice their initial length and maintain electrical conduction. We review the fabrication of these conductors, present their electrical and mechanical properties, and summarize our model for their extreme stretchability. Using such stretchable interconnects, we made the first elastic circuit, an inverter of thin film transistors. The circuit remains functional when stretched and relaxed by 12% strain.

/pdf/stretchable-interconnects-for-elastic-electronic-surfaces-2ni70j6r2r.pdf

Stretchable Interconnects for Elastic Electronic Surfaces

Sensitive skin is a large-area, flexible array of sensors with data processing capabilities, which can be used to cover the entire surface of a machine or even a part of a human body. Depending on the skin electronics, it endows its carrier with an ability to sense its surroundings via the skin’s proximity, touch, pressure, temperature, chemical/biological, or other sensors. Sensitive skin devices will make possible the use of unsupervised machines operating in unstructured, unpredictable surroundings—among people, among many obstacles, outdoors on a crowded street, undersea, or on faraway planets. Sensitive skin will make machines “cautious” and thus friendly to their environment. This will allow us to build machine helpers for the disabled and elderly, bring sensing to human prosthetics, and widen the scale of machines’ use in service industry. With their ability to produce and process massive data flow, sensitive skin devices will make yet another advance in the information revolution. This paper surveys the state of the art and research issues that need to be resolved in order to make sensitive skin a reality. The paper is partially based on the report of the Sensitive Skin Workshop conducted jointly by the National Science Foundation (NSF) and Defense Advanced Research Projects Agency (DARPA) in October 1999 in Arlington, VA, of which the three co-authors were the co-chairs [1].

Sensitive Skin

Gold films on an elastomeric substrate can be stretched and relaxed reversibly by tens of percent. The films initially form in two different structures, one continuous and the other containing tribranched microcracks. We have identified the mechanism of elastic stretchability in the films with microcracks. The metal, which is much stiffer than the elastomer, forms a percolating network. To accommodate the large elongation of the elastomeric substrate, the metal network twists and deflects out of the plane but remains bonded to the soft substrate. Consequently, the metal film experiences only small strains and deforms elastically without suffering fatigue.

/pdf/mechanisms-of-reversible-stretchability-of-thin-metal-films-1uhcl8za69.pdf

Sigurd Wagner

Papers

Stretchable gold conductors on elastomeric substrates

Mechanics of rollable and foldable film-on-foil electronics

Stretchable Interconnects for Elastic Electronic Surfaces

Sensitive Skin

Mechanisms of reversible stretchability of thin metal films on elastomeric substrates