Sijin Wu

TL;DR: It is found that a chronic stress–induced cancer stem-like phenotype could be reversed by vitamin C, and the LDHA-lowering agent vitamin C can be a potential approach for combating stress-associated breast cancer.

TL;DR: This study demonstrates that Hc-CATH, the first cathelicidin from sea snake discovered to have both antimicrobial and anti-inflammatory activity, is a potent candidate for the development of peptide antibiotics.

TL;DR: A novel effect of flubendazole is demonstrated on suppressing breast CS-like cells and enhanced cytotoxic activity of conventional therapeutic drugs fluorouracil and doxorubicin against breast cancer cells.

TL;DR: Exome sequencing of ENKTL tumor–normal samples has identified a hotspot mutation in the evolutionarily conserved signaling intermediate in Toll pathway (ECSIT) gene, encoding a V140A variant of ECSIT, associated with activation of NF-κB, higher HPS incidence, and poor prognosis in individuals with ENkTL.

TL;DR: It is shown that CRM1, an important nuclear exportin, is a cellular target of curcumin by serious experimental and theoretical investigation, and computational modeling has revealed thatCurcumin could be correctly docked into the hydrophobic pocket ofCRM1 judged from shape complementarity and putative molecular interactions.