AIE-featured tetraphenylethylene nanoarchitectures in biomedical application: Bioimaging, drug delivery and disease treatment

A simple D–π–A structured tetraphenylethylene with two electron-rich methyloxy groups and two electron withdrawing cyano groups, which features both twisted intramolecular charge-transfer (TICT) and aggregation-induced emission (AIE) properties, namely TPEOMeCN has been prepared. The emission of TPEOMeCN examined in various solvents is dependent on the polarities of solvents, which indicates the TICT character. The emission intensity of the compound also enhances with the increasing water fraction in H2O–DMSO mixtures, demonstrating the typical AIE property. Excitingly, the TICT and AIE emission could be observed separately or simultaneously by adjusting the water fraction or viscosity of the solvent. Encouragingly, the combined emission of the TPEOMeCN derived from this single molecule could be readily tuned via regulating the viscosity of the system, resulting in a broad emission peak which covers the visible spectrum (400–700 nm). This work provides a general strategy for designing molecules combining TICT emission and AIE for application as full-color emitters.

https://pubs.rsc.org/en/content/articlepdf/2020/ra/d0ra00107d

Tuning the fluorescence based on the combination of TICT and AIE emission of a tetraphenylethylene with D–π–A structure

A set of fluorene-capped pendant conjugated molecules (T-m and T-p), which consist of a triazine center with three carbazole substituents as the donor-acceptor (D-A) type pendant structure, were designed, synthesized, and investigated as gain media for organic semiconductor lasers (OSLs). In particular, varying the capping positions of the fluorene units on the pendant core structures results in significantly different intramolecular charge transfer (ICT) properties, where T-m manifested depressed ICT characteristic and high fluorescence quantum yield. The lowest amplified spontaneous emission (ASE) threshold in neat films was recorded as 1.9 μJ cm-2 for T-m and 83.8 μJ cm-2 for T-p, which indicated that the depressed ICT characteristics in the case of T-m help to enhance the ASE properties. Remarkably, the ASE threshold remained almost unchanged and the ASE spectra showed very small shifts (within 1 nm) for T-m with film samples annealed up to 180 °C in open air. In contrast, its linear counterpart 2FEtCz-m showed a clearly increased ASE threshold upon annealing above 100 °C. The results suggest that the selective construction of conjugated pendant molecules with depressed ICT characteristics is beneficial for finely modulating the optical and electrical properties as well as improving the thermostability and photostability, which manifests the great potential as a robust gain media for OSLs.

Donor–Acceptor Type Pendant Conjugated Molecules Based on a Triazine Center with Depressed Intramolecular Charge Transfer Characteristics as Gain Media for Organic Semiconductor Lasers

Tunable linear and nonlinear optical properties of chromophores containing 3,7-(di)vinylquinoxalinone core by modification of receptors moieties

Exceptional aggregation-induced emission from one totally planar molecule

Study on TICT emission of TPE-BODIPY derivatives mediated by methyl group on BODIPY

Relationship between cis-trans isomerism and optical and electrical properties based on benzidiimidazole-thiophene copolymer

Biogenic amines are present in large quantities in fermented foods and are a key marker for assessing food safety. This paper proposes a novel method for high-performance liquid chromatography analysis of biogenic amines using deep eutectic solvent as mobile phase additive. After screening eight synthetic deep eutectic solvents and comparing with several common additives, deep eutectic solvents based on choline chloride and ethylene glycol showed significant effects for improving the separation of biogenic amines. A Box-Behnken design of 17 runs was used to screen and optimize the key chromatographic parameters, resulting in an expected composition of the mobile phase of 0.73% deep eutectic solvent, 65% acetonitrile, and a column temperature of 28°C. The proposed method exhibited excellent linearity (0.1-50 μg/mL, R2 ≥ 0.9987), limit of detection (0.007-0.031 μg/mL), precision (1.28-5.34%) and accuracy (87.2-110.6%). The method can be applied successfully to the separation and analysis of biogenic amines in cooking wine samples. This article is protected by copyright. All rights reserved.

Utilization of ionic deep eutectic solvent as sustainable mobile phase additive in HPLC for improving the separation of biogenic amines.

ZIF-8@SiO2 based novel dispersive solid-phase filter extraction technique for the purification of laminarin and fucoidan from undaria pinnatifida

Isoflavone exhibits estrogen-like structure and activity and has various physiological and pharmacological functions, such as anticancer, antioxidant, and anti-inflammatory. In this study, several deep eutectic solvents (DESs) were synthesized and used as mobile phase additives to optimize the analytical conditions of five isoflavones. The DES composed of choline chloride:citric acid (molar ratio 1:1) was the most effective mobile phase additive with reduced peak tailing, improved peak shape, and increased number of theoretical plates. The effectiveness of the DES highlights its potential as a mobile phase additive. The optimal high-performance liquid chromatography (HPLC) conditions for the isoflavones were determined by the Intelligent HPLC simulator. The optimal conditions for gradient elution were water (A): acetonitrile (B) for 0 min, 25% B; 15 min, 25% B; 17 min, 35% B; and 50 min, 35% B. This approach provided excellent linearity (0.5 to 500 μg/mL, R2 ≥ 0.9991), limits of detection (0.024 to 0.109 μg/mL), limits of quantification (0.079 to 0.363 μg/mL), and precision (1.74 to 4.80%). 

Optimization of High-Performance Liquid Chromatography (HPLC) Conditions for Isoflavones Using Deep Eutectic Solvents (DESs) as Mobile Phase Additives by the HCI Program

Sile He

Papers

Study on TICT emission of TPE-BODIPY derivatives mediated by methyl group on BODIPY

Relationship between cis-trans isomerism and optical and electrical properties based on benzidiimidazole-thiophene copolymer

Utilization of ionic deep eutectic solvent as sustainable mobile phase additive in HPLC for improving the separation of biogenic amines.

ZIF-8@SiO2 based novel dispersive solid-phase filter extraction technique for the purification of laminarin and fucoidan from undaria pinnatifida

Optimization of High-Performance Liquid Chromatography (HPLC) Conditions for Isoflavones Using Deep Eutectic Solvents (DESs) as Mobile Phase Additives by the HCI Program