S
Silvia Ravera
Researcher at University of Genoa
Publications - 217
Citations - 4435
Silvia Ravera is an academic researcher from University of Genoa. The author has contributed to research in topics: Mitochondrion & ATP synthase. The author has an hindex of 33, co-authored 190 publications receiving 3444 citations. Previous affiliations of Silvia Ravera include Istituto Giannina Gaslini & University of Zurich.
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Journal ArticleDOI
The Arabidopsis vacuolar malate channel is a member of the ALMT family
Peter Kovermann,Stefan Meyer,Stefan Hörtensteiner,Cristiana Picco,Joachim Scholz-Starke,Silvia Ravera,Youngsook Lee,Enrico Martinoia,Enrico Martinoia +8 more
TL;DR: Deletion mutants for AtALMT9 exhibit only slightly reduced malate content in mesophyll protoplasts and no visible phenotype, indicating that AttDT and the residual malate channel activity are sufficient to sustain the transport activity necessary to regulate the cytosolic malate homeostasis.
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The Sodium/Iodide Symporter (NIS): Molecular Physiology and Preclinical and Clinical Applications
TL;DR: This review focuses on the most recent findings on I- homeostasis and I- transport deficiency-causing NIS mutations, as well as current knowledge of the structure/function properties of NIS and NIS regulatory mechanisms.
Journal ArticleDOI
The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi
Ricardo Villa-Bellosta,Silvia Ravera,Victor Sorribas,Gerti Stange,Moshe Levi,Heini Murer,Jürg Biber,Ian C. Forster +7 more
TL;DR: It is shown that a member of the SLC20 gene family (PiT-2) is localized to the brush-border membrane (BBM) of the PT epithelia and that its abundance, confirmed by Western blot and immunohistochemistry of rat kidney slices, is regulated by dietary P(i).
Journal ArticleDOI
Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
Giovanna Bianchi,Roberto Martella,Silvia Ravera,Cecilia Marini,Selene Capitanio,Annamaria Orengo,Laura Emionite,Chiara Lavarello,Adriana Amaro,Andrea Petretto,Ulrich Pfeffer,Gianmario Sambuceti,Vito Pistoia,Lizzia Raffaghello,Valter D. Longo +14 more
TL;DR: Findings indicate that the glucose and amino acid deficiency conditions imposed by STS promote an anti-Warburg effect characterized by increased oxygen consumption but failure to generate ATP, resulting in oxidative damage and apoptosis.
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Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer
Cecilia Marini,Barbara Salani,Michela Massollo,Adriana Amaro,Alessia Isabella Esposito,Anna Maria Orengo,Selene Capitanio,Laura Emionite,Mattia Riondato,Gianluca Bottoni,Cinzia Massara,Simona Boccardo,Marina Fabbi,Cristina Campi,Silvia Ravera,Giovanna Angelini,Silvia Morbelli,Michele Cilli,Renzo Cordera,Mauro Truini,Davide Maggi,Ulrich Pfeffer,Gianmario Sambuceti +22 more
TL;DR: It is demonstrated that metformin directly inhibits the enzymatic function of hexokinase (HK) I and II in a cell line of triple-negative breast cancer (MDA-MB-231), and results strongly suggest that HK inhibition contributes to met formin therapeutic and preventive potential in breast cancer.