S
Simon Kang Seng Ting
Researcher at Singapore General Hospital
Publications - 41
Citations - 278
Simon Kang Seng Ting is an academic researcher from Singapore General Hospital. The author has contributed to research in topics: Dementia & Medicine. The author has an hindex of 8, co-authored 35 publications receiving 185 citations. Previous affiliations of Simon Kang Seng Ting include SingHealth.
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Journal ArticleDOI
Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer's Disease and Amnestic Mild Cognitive Impairment.
Yi Jayne Tan,Yi Jayne Tan,Adeline S.L. Ng,Ashwati Vipin,Joseph Lim,Russell J. Chander,Fang Ji,Yingwei Qiu,Simon Kang Seng Ting,Shahul Hameed,Tih-Shih Lee,Li Zeng,Nagaendran Kandiah,Juan Zhou,Juan Zhou +14 more
TL;DR: Peripheral TREM2 mRNA levels are higher in AD and are associated with AD-related cognitive deficits and hippocampal atrophy, suggesting that TREM 2 may be a potential non-invasive peripheral biomarker for AD diagnosis.
Journal ArticleDOI
NOTCH2NLC GGC Repeat Expansions Are Associated with Sporadic Essential Tremor: Variable Disease Expressivity on Long-Term Follow-up.
Adeline S.L. Ng,Adeline S.L. Ng,Weng Khong Lim,Zheyu Xu,Helen L. Ong,Yi Jayne Tan,Wei Ying Sim,Ebonne Yulin Ng,Jing Xian Teo,Jia Nee Foo,Jia Nee Foo,Tchoyoson C.C. Lim,Wai-Yung Yu,Ling Ling Chan,Hwei-Yee Lee,Zhiyong Chen,Ee-Wei Lim,Simon Kang Seng Ting,Kumar M. Prakash,Louis C.S. Tan,Zhao Yi,Eng-King Tan,Eng-King Tan +22 more
TL;DR: Carriers presenting with a pure ET phenotype may or may not convert to NIID up to four decades after initial tremor onset, and no GGC repeats above 60units were detected in familial ET cases and controls, though four ET patients carried 47-53 "intermediate" repeats.
Journal ArticleDOI
Absence of A673T amyloid-β precursor protein variant in alzheimer's disease and other neurological diseases
Simon Kang Seng Ting,Mei Sian Chong,Nagaendran Kandiah,Shahul Hameed,Louis C.S. Tan,Wing Lok Au,Kumar M. Prakash,R. Pavanni,Tih-Shih Lee,Jia Nee Foo,Jin Xin Bei,Jin Xin Bei,Xue Qing Yu,Jianjun Liu,Jianjun Liu,Yi Zhao,Wei Ling Lee,Eng-King Tan +17 more
TL;DR: The finding suggests that the A673T protective variant is not relevant in the Asian population, and studies in other ethnic populations would clarify whether this variant is specific to specific races/ethnicities.
Journal ArticleDOI
Phenotypic bases of NOTCH2NLC GGC expansion positive neuronal intranuclear inclusion disease in a Southeast Asian cohort
Zhiyong Chen,Zheyu Xu,Qianhui Cheng,Yi Jayne Tan,Helen L. Ong,Yi Zhao,Weng Khong Lim,Jing Xian Teo,Jia Nee Foo,Jia Nee Foo,Hwei Yee Lee,Jeanne M.M. Tan,Liting Hang,Wai-Yung Yu,Simon Kang Seng Ting,Eng-King Tan,Eng-King Tan,Tchoyoson C.C. Lim,Adeline S.L. Ng,Adeline S.L. Ng +19 more
TL;DR: Overall, a cohort of genetically confirmed NIID patients from Southeast Asia are described and it is provided that the presence of GGA interruptions within GGC repeat expansions may serve as a potential genetic modifier in NIID.
Journal ArticleDOI
Regional White Matter Hyperintensity Influences Grey Matter Atrophy in Mild Cognitive Impairment
Ashwati Vipin,Heidi Jing Ling Foo,Joseph Lim,Russell J. Chander,Ting Ting Yong,Adeline Su Lyn Ng,Shahul Hameed,Simon Kang Seng Ting,Juan Zhou,Juan Zhou,Nagaendran Kandiah +10 more
TL;DR: Although WMH volume was highest in AD subjects, it had a more pervasive influence on brain structure and cognitive impairment in MCI, highlighting the importance of early detection of cerebrovascular disease, as its intervention at the MCI stage might potentially slow down neurodegeneration.