S
Simon Müller
Researcher at Martin Luther University of Halle-Wittenberg
Publications - 14
Citations - 596
Simon Müller is an academic researcher from Martin Luther University of Halle-Wittenberg. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 6, co-authored 11 publications receiving 296 citations.
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Journal ArticleDOI
IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner
Simon Müller,Markus Glaß,Anurag Kumar Singh,Jacob Haase,Nadine Bley,Tommy Fuchs,Marcell Lederer,Andreas Dahl,Huilin Huang,Huilin Huang,Jianjun Chen,Jianjun Chen,Guido Posern,Stefan Hüttelmaier +13 more
TL;DR: Findings identify the SRF/IGF2BP1, miRNome- and m6A-dependent control of gene expression as a conserved oncogenic driver network in cancer.
Journal ArticleDOI
IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors.
Simon Müller,Nadine Bley,Markus Glaß,Bianca Busch,Vanessa Rousseau,Danny Misiak,Tommy Fuchs,Marcell Lederer,Stefan Hüttelmaier +8 more
TL;DR: Findings indicate that IGF2BP1 enhances an aggressive tumor cell phenotype by antagonizing miRNA-impaired gene expression.
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The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family.
Bianca Busch,Nadine Bley,Simon Müller,Markus Glaß,Danny Misiak,Marcell Lederer,Martina Vetter,Hans-Georg Strauß,Christoph Thomssen,Stefan Hüttelmaier +9 more
TL;DR: The targeting of the HMGA2-LIN28B-IGF2BP1 triangle is suggested as a promising strategy in cancer treatment because the expression of the triangle factors is inversely correlated with let-7 levels and promoted by LIN28B impairingLet-7 biogenesis.
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The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer.
Simon Müller,Nadine Bley,Bianca Busch,Markus Glaß,Marcell Lederer,Claudia Misiak,Tommy Fuchs,Alice Wedler,Jacob Haase,Jean B. Bertoldo,Patrick Michl,Stefan Hüttelmaier +11 more
TL;DR: It is revealed that IGF2BP1 is a post-transcriptional enhancer of the E2F-driven hallmark in solid cancers, and the small molecule BTYNB disrupts this enhancer function by impairing IGF2 BP1-RNA association.
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Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3
Tim Schneider,Lee Hsueh Hung,Masood Aziz,Anna Wilmen,Stephanie Thaum,Jacqueline Wagner,Robert Janowski,Simon Müller,Silke Schreiner,Peter Friedhoff,Stefan Hüttelmaier,Dierk Niessing,Michael Sattler,Andreas Schlundt,Andreas Schlundt,Albrecht Bindereif +15 more
TL;DR: This approach identifies the RNA-binding specificity and RNP topology of IMP3, involving all six RBDs and a cluster of up to five distinct and appropriately spaced CA-rich and GGC-core RNA elements, covering a >100 nucleotide-long target RNA region.