Author
Simona Collina
Other affiliations: Università degli Studi Suor Orsola Benincasa, University of Trieste, University of Edinburgh ...read more
Bio: Simona Collina is an academic researcher from University of Pavia. The author has contributed to research in topics: Enantiomer & Chiral column chromatography. The author has an hindex of 28, co-authored 175 publications receiving 3234 citations. Previous affiliations of Simona Collina include Università degli Studi Suor Orsola Benincasa & University of Trieste.
Papers published on a yearly basis
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TL;DR: PET was used to measure regional cerebral activity during tasks requiring reading of concrete and abstract nouns and verbs for lexical decision and indicated that abstract word processing was associated with selective activations, which is compatible with the view that lexical-semantic processing of words is mediated by an extensive, predominantly left hemispheric network of brain structures.
Abstract: The hypothesis that categorical information, distinguishing among word classes, such as nouns, verbs, etc., is an organizational principle of lexical knowledge in the brain, is supported by the observation of aphasic subjects who are selectively impaired in the processing of nouns and verbs. The study of lesion location in these patients has suggested that the left temporal lobe plays a crucial role in processing nouns, while the left frontal lobe is necessary for verbs. To delineate the brain areas involved in the processing of different word classes, we used PET to measure regional cerebral activity during tasks requiring reading of concrete and abstract nouns and verbs for lexical decision. These tasks activated an extensive network of brain areas, mostly in the left frontal and temporal cortex, which represents the neural correlate of single word processing. Some left hemispheric areas, including the dorsolateral frontal and lateral temporal cortex, were activated only by verbs, while there were no brain areas more active in response to nouns. Furthermore, the comparison of abstract and concrete words indicated that abstract word processing was associated with selective activations (right temporal pole and amygdala, bilateral inferior frontal cortex), while no brain areas were more active in response to concrete words. There were no significant interaction effects between word class and concreteness. Taken together, these findings are compatible with the view that lexical-semantic processing of words is mediated by an extensive, predominantly left hemispheric network of brain structures. Additional brain activations appear to be related to specific semantic content, or, in the case of verbs, may be associated with the automatic access of syntactic information.
468 citations
Flinders University1, Centre national de la recherche scientifique2, University of Mons3, University of Arizona4, Comenius University in Bratislava5, University of Tennessee Health Science Center6, University of North Texas Health Science Center7, University of Eastern Finland8, University of Pavia9, University of Pisa10, University of Porto11, Aix-Marseille University12, University of Naples Federico II13, Al-Quds University14, University of Basilicata15, National and Kapodistrian University of Athens16, University of Barcelona17, Aristotle University of Thessaloniki18, University of Calabria19, University of Bonn20, Sapienza University of Rome21, University of Orléans22
TL;DR: Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials published on a biannual basis by the Editorial Board of the Medicinal chemistry section of the journal Molecules.
Abstract: Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials, which are published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...].
186 citations
TL;DR: One of the latest research approaches focuses on modifying the delivery mode to improve tumour cell uptake and reduce toxicity.
170 citations
TL;DR: The state-of-art of VAs is reviewed, discussing their mechanism of action and pharmacokinetic properties and highlighting their therapeutic relevance and toxicological profile, as well as the recent advances in the discovery of new derivatives.
169 citations
TL;DR: This work summarizes the mechanism of action, chemical, and anticancer profile of the DHFR inhibitors discovered in the last six years in order to thoroughly delineate the current landscape for medicinal chemists interested in furthering this study in the anticancer field.
Abstract: Dihydrofolate reductase inhibitors are an important class of drugs, as evidenced by their use as antibacterial, antimalarial, antifungal, and anticancer agents. Progress in understanding the biochemical basis of mechanisms responsible for enzyme selectivity and antiproliferative effects has renewed the interest in antifolates for cancer chemotherapy and prompted the medicinal chemistry community to develop novel and selective human DHFR inhibitors, thus leading to a new generation of DHFR inhibitors. This work summarizes the mechanism of action, chemical, and anticancer profile of the DHFR inhibitors discovered in the last six years. New strategies in DHFR drug discovery are also provided, in order to thoroughly delineate the current landscape for medicinal chemists interested in furthering this study in the anticancer field.
125 citations
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Book•
28 Apr 2011
TL;DR: The authors, The Neuropsychology of language and its relationship with the human brain: A Guide to Research on the Perception of Speech and its Implications for Research and Theory, The authors.
Abstract: K. Haberlandt, Methods in Reading Research. F. Ferreira and M. Anes, Why Study Spoken Language? K. Rayner and S.C. Sereno, Eye Movements in Reading Psycholinguistic Studies. M. Kutas and C.K. Van Petten, Psycholinguistics Electrified: Event-Related Brain Potential Investigations. R.E. Remez, A Guide to Research on the Perception of Speech. K.R. Kluender, Speech Perception as a Tractable Problem in Cognitive Science. D.W. Massaro, Psychological Aspects of Speech Perception: Implications for Research and Theory. S.E. Lively, D.B. Pisoni, and S.D. Goldinger, Spoken Word Recognition: Research and Theory. D.A. Balota, Visual Word Recognition: The Journey from Features to Meaning. G.B. Simpson, Context and the Processing of Ambiguous Words. D.C. Mitchell, Sentence Parsing. R.W. Gibbs, Jr., Figurative Thought and Figurative Language. C. Cacciari and S. Glucksberg, Understanding Figurative Language. M. Singer, Discourse Inference Processes. A.C. Graesser, C.L. McMahen, and B.K. Johnson, Question Asking and Answering. P. van den Broek, Comprehension and Memory of Narrative Texts: Inferences and Coherence. C.R. Fletcher, Levels of Representation in Memory for Discourse. A.M. Glenberg, P. Kruley, and W.E. Langston, Analogical Processes in Comprehension: Simulation of a Mental Model. B.K. Britton, Understanding Expository Text: Building Mental Structures to Induce Insights. S.C. Garrod and A.J. Sanford, Resolving Sentences in a Discourse Context: How Discourse Representation Affects Language Understanding. A.J. Sanford and S.C. Garrod, Selective Processing in Text Understanding. W. Kintsch, The Psychology of Discourse Processing. P. Bloom, Recent Controversies in the Study of Language Acquisition. L. Gerken, Child Phonology: Past Research, Present Questions, Future Directions. J. Oakhill, Individual Differences in Children's Text Comprehension. C.A. Perfetti, Psycholinguistics and Reading Ability. R.K. Olson, Language Deficits in Specific Reading Disability. K. Kilborn, Learning a Language Late: Second Language Acquisition in Adults. K. Bock and W. Levelt, Language Production: Grammatical Encoding. H.H. Clark, Discourse in Production. D. Caplan, Language and the Brain. E. Zurif and D. Swinney, The Neuropsychology of Language. P.A. Carpenter, A. Miyake, and M.A Just, Working Memory Constraints in Comprehension: Evidence from Individual Differences, Aphasia, and Aging. A. Garnham, Future Directions. Index.
1,926 citations
TL;DR: An anatomical model is presented that indicates the location of the language areas and the most consistent functions that have been assigned to them and the implications for cognitive models of language processing are considered.
1,700 citations
TL;DR: A large-scale meta-analysis of language literature sheds light on the fine-scale functional architecture of the inferior frontal gyrus for phonological and semantic processing, the evidence for an elementary audio-motor loop involved in both comprehension and production of syllables, and the hypothesis that different working memory perception-actions loops are identifiable for the different language components.
1,596 citations
1,390 citations
TL;DR: It is scarcely an exaggeration to say that the recently issued preliminary report on the census of 1931 is one of the most sensational documents which has appeared for years, and that he who reads it intelligently will understand what is meant by saying that civilisation is in the melting pot.
Abstract: QUITE apart from the academic consideration that vital and medical statistics now form an obligatory part of the education of students seeking the University of London's diploma in public health, the demand for information about the methods of vital and medical statistics is increasing. The most casual reader of the newspapers is now aware that population problems are of serious practical importance and that the publications of the General Register Office cannot be ignored. It is scarcely an exaggeration to say that the recently issued preliminary report on the census of 1931 is one of the most sensational documents which has appeared for years, and that he who reads it intelligently will understand what is meant by saying that civilisation is in the melting pot. An Introduction to Medical Statistics. By Hilda M. Woods William T. Russell. Pp. x + 125. (London: P. S. King and Son, Ltd., 1931.) 7s. 6d.
1,329 citations