Simone Becattini

TL;DR: The most recently discovered connections between host pathophysiology, microbiota, and antibiotics are reviewed highlighting technological platforms, mechanistic insights, and clinical strategies to enhance resistance to diseases by preserving the beneficial functions of the microbiota.

TL;DR: By combining antigenic stimulation and T cell receptor deep sequencing, this work finds that human pathogen- and vaccine-specific T helper 1 (TH1), TH2, and TH17 memory cells have different frequencies but comparable diversity and comprise not only clones polarized toward a single fate, but also clones whose progeny have acquired multiple fates.

TL;DR: It is shown that a diverse microbiota markedly reduces Listeria monocytogenes colonization of the gut lumen and prevents systemic dissemination, and identifies intestinal commensal species that, by enhancing resistance against this pathogen, represent potential probiotics.

TL;DR: It is shown that BPSCSK reduces growth of VRE by secreting a lantibiotic that is similar to the nisin-A produced by Lactococcus lactis, which represents potential probiotic agents to re-establish resistance to VRE.

TL;DR: The use of neutralizing antibodies to identify the most effective antigen has been proposed as a strategy to design vaccines capable of eliciting protective B-cell immunity and these results illustrate with a relevant example a general and practical approach of analytic vaccinology for the development of subunit vaccines against complex pathogens.