Simone Cenci

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: The ability of estrogen to target T cells, suppressing their production of TNF-alpha, is a key mechanism by which estrogen prevents osteoclastic bone resorption and bone loss.

TL;DR: It is found that ovariectomy increased the number of bone marrow T cell-producing TNF without altering production of TNF per T cell, demonstrating the key causal role of Tcell-produced TNF in the bone loss after estrogen withdrawal.

TL;DR: Autophagy is specifically required for plasma cell homeostasis and long-lived humoral immunity and its function is investigated through the use of mice with conditional deficiency in the essential autophagic molecule Atg5 in B cells.