Author
Simonetta Masieri
Other affiliations: Policlinico Umberto I
Bio: Simonetta Masieri is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Asthma & Allergen immunotherapy. The author has an hindex of 14, co-authored 63 publications receiving 499 citations. Previous affiliations of Simonetta Masieri include Policlinico Umberto I.
Topics: Asthma, Allergen immunotherapy, Medicine, Omalizumab, Allergy
Papers published on a yearly basis
Papers
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TL;DR: Noise exposure during noninvasive ventilation with different types of interface (helmet, nasal, and facial masks) is associated with significantly greater noise but is as comfortable as masks, at least in the short term.
Abstract: To assess noise exposure during noninvasive ventilation (NIV) with different types of interface (helmet, nasal, and facial masks). Ten “naive” healthy volunteers underwent NIV at pressure support levels of 10 and 15 cmH2O with: (a) helmet, (b) helmet equipped with HME filters at the junctions between the helmet and the inspiratory and expiratory branches of the respiratory circuit, (c) nasal mask, and (d) facial mask. Noise intensity was assessed with a sound level meter by placing a microphone near the right ear. Noise intensity and degree of discomfort were also assessed subjectively with a visual analogue scale. Inside the helmet noise exceeded 100 dB. Noise intensity was poorly affected by pressure support level and unaffected by the presence of HME filters. During NIV with nasal or facial masks the noise did not exceed 70 dB (i.e., noise was not louder than the usual noise background in ICU). Subjective evaluation of noise intensity mirrored objective measurements; however, the presence of HME filters was associated with the feeling of less noise inside the helmet. The discomfort associated with the helmet did not significantly differ from that associated with the masks. NIV helmet is associated with significantly greater noise than nasal and facial masks, but is as comfortable as masks, at least in the short term. Medium- and long-term exposure to loud noise may potentially impair ear function and increase the patient’s discomfort.
48 citations
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TL;DR: In real-life, MEP improved significantly all outcomes even small airway obstruction, suggesting its possible role also in distal lung region treatment.
41 citations
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TL;DR: The first 48 hours after surgery is a critical period in high-risk patients, and a stay in the S-ICU should be seriously considered, as suggested by the highly significant difference between expected and observed deaths following S- ICU admission.
Abstract: Background Postoperative admission to the surgical intensive care unit (S-ICU) is routinely planned in order to prevent and treat early complications. Currently, limited studies have been conducted on this topic, and as such, early morbidity and mortality in patients undergoing postoperative intensive care were investigated. Methods This prospective analysis was performed in the S-ICU of a University hospital and included 1045 consecutive patients. All patients underwent elective surgery and were admitted to the S-ICU on the basis of preoperative clinical assessment. On the second, seventh, and thirtieth postoperative days, the location of the patients was recorded (ICU, surgical ward, or home) as were any complications that occurred. Predicted mortality and morbidity were assessed using the POSSUM score. Results The observed postoperative mortality rate was 2.4% (95% CI: 1.5-3.3%), which was much lower than the rate predicted by both POSSUM (6.2%) and P-POSSUM (5.3%) analyses, and 36% of patients experienced complications, a percentage slightly higher than that predicted by POSSUM (30.2%). The first 48 hours following surgery were characterized by the highest mortality rate (2.85 deaths per thousand vs 0.7 per thousand by the third postoperative day) as well as the highest morbidity rate (7.7% vs 4.3% between the third and seventh postoperative days, and 0.9% between the eighth and thirtieth postoperative days). The presumed causes of early death were primarily secondary to cardiovascular complications (five out of six). Conclusions The first 48 hours after surgery is a critical period in high-risk patients, and a stay in the S-ICU should be seriously considered. Planned admission to the S-ICU may effectively decrease postoperative mortality, as suggested by the highly significant difference between expected and observed deaths following S-ICU admission.
40 citations
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TL;DR: Age, obesity, comorbidities, smoking habits, nasal polyps, allergic poly-sensitization might reduce Omalizumab effectiveness independently to other asthma-influencing factors.
37 citations
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TL;DR: Noise intensity and perceived noisiness during continuous positive airway pressure (CPAP) performed with two interfaces (face‐mask, helmet) and four delivery systems are measured.
Abstract: Background: We measured noise intensity and perceived noisiness during continuous positive airway pressure (CPAP) performed with two interfaces (face-mask, helmet) and four delivery systems.
Methods: Eight healthy volunteers received CPAP in random order with: two systems provided with a flow generator using the Venturi effect and a mechanical expiratory valve (A: Venturi, Starmed; B: Whisperflow-2, Caradyne Ltd); one ‘free-flow’ system provided with high flow O2 and air flowmeters, an inspiratory gas reservoir, and a water valve (C: CF800, Dragerwerk, AG); and a standard mechanical ventilator (Servoventilator 300, Siemens-Elema). Systems A, B, and C were tested with a face-mask and a helmet at a CPAP value of 10 cm H2O; the mechanical ventilator was only tested with the face mask. Noise intensity was measured with a sound-level meter. After each test, participants scored noisiness on a visual analog scale (VAS).
Results: The noise levels measured ranged from 57±11 dBA (mechanical ventilator plus mask) to 93±1 and 94±2 dBA (systems A and B plus helmet) and were significantly affected by CPAP systems (A and B noisier than C and D) and interfaces (helmet CPAP noisier than mask CPAP). Subjective evaluation showed that systems A and B plus helmet were perceived as noisier than system C plus mask or helmet.
Conclusions: Maximum noise levels observed in this study may potentially cause patient discomfort. Less noisy CPAP systems (not using Venturi effect) and interfaces (facial mask better than helmet) should be preferred, particularly for long or nocturnal treatments.
36 citations
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TL;DR: This paper focuses on hot pepper, which is eaten on a daily basis by an estimated one-quarter of the world’s population and has potential to be a biological target for regenerative medicine.
Abstract: Natural products afford a window of opportunity to study important biology. If the natural product is used or abused by human beings, finding its biological target(s) is all the more significant. Hot pepper is eaten on a daily basis by an estimated one-quarter of the world’s population and
1,848 citations
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University Hospital Southampton NHS Foundation Trust1, St Mary's Hospital2, University of Southampton3, Heidelberg University4, Swiss Institute of Allergy and Asthma Research5, National Institutes of Health6, Erasmus University Rotterdam7, Odense University Hospital8, Nippon Medical School9, University of Cyprus10, University of Edinburgh11, Charité12, University of Messina13, Eskişehir Osmangazi University14, Boston Children's Hospital15, Katholieke Universiteit Leuven16, Utrecht University17, Johns Hopkins University18, Athens State University19, University Medical Center Groningen20, University of Milan21, University College Hospital22, King's College London23, Medical University of Graz24, European Union25, Capital Medical University26, Transylvania University27, Northern General Hospital28, Hospital Clínico San Carlos29, Wrocław Medical University30, University of Amsterdam31, University of Padua32
TL;DR: In general, broad evidence for the clinical efficacy of AIT for AR exists but a product‐specific evaluation of evidence is recommended, and SCIT and SLIT are recommended for both seasonal and perennial AR for its short‐term benefit.
Abstract: Allergic rhinoconjunctivitis (AR) is an allergic disorder of the nose and eyes affecting about a fifth of the general population. Symptoms of AR can be controlled with allergen avoidance measures and pharmacotherapy. However, many patients continue to have ongoing symptoms and an impaired quality of life; pharmacotherapy may also induce some side-effects. Allergen immunotherapy (AIT) represents the only currently available treatment that targets the underlying pathophysiology, and it may have a disease-modifying effect. Either the subcutaneous (SCIT) or sublingual (SLIT) routes may be used. This Guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Taskforce on AIT for AR and is part of the EAACI presidential project "EAACI Guidelines on Allergen Immunotherapy." It aims to provide evidence-based clinical recommendations and has been informed by a formal systematic review and meta-analysis. Its generation has followed the Appraisal of Guidelines for Research and Evaluation (AGREE II) approach. The process included involvement of the full range of stakeholders. In general, broad evidence for the clinical efficacy of AIT for AR exists but a product-specific evaluation of evidence is recommended. In general, SCIT and SLIT are recommended for both seasonal and perennial AR for its short-term benefit. The strongest evidence for long-term benefit is documented for grass AIT (especially for the grass tablets) where long-term benefit is seen. To achieve long-term efficacy, it is recommended that a minimum of 3 years of therapy is used. Many gaps in the evidence base exist, particularly around long-term benefit and use in children.
436 citations
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Emory University1, Johns Hopkins University2, Temple University3, University of Utah4, Swiss Institute of Allergy and Asthma Research5, University of Chicago6, Ghent University7, Humanitas University8, Eskişehir Osmangazi University9, Imperial College London10, University of California, San Diego11, University of North Carolina at Chapel Hill12, Rutgers University13, University of Amsterdam14, University of Missouri15, University of Texas Southwestern Medical Center16, Aarhus University17, Hannover Medical School18, Case Western Reserve University19, Stanford University20, Harvard University21, University of Turku22, University of Colorado Boulder23, University of Texas at Austin24, San Antonio Military Medical Center25, University of Pittsburgh26, University of Texas Health Science Center at Houston27, Ochsner Health System28, Uniformed Services University of the Health Sciences29, Karolinska Institutet30, Wake Forest University31, University of Pavia32, University of Barcelona33, University of Colorado Denver34, Loyola University Chicago35, Nippon Medical School36, Heidelberg University37, Boston University38, Cornell University39, University of Calgary40, Medical University of South Carolina41, Brown University42, George Washington University43, University of Edinburgh44, Oregon Health & Science University45, Mahidol University46, National University of Singapore47, University of Michigan48
TL;DR: To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR).
Abstract: BACKGROUND:
Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR).
METHODS:
Using previously described methodology, specific topics were developed relating to AR. Each topic was assigned a literature review, evidence-based review (EBR), or evidence-based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for consensus.
RESULTS:
The ICAR:AR document addresses over 100 individual topics related to AR, including diagnosis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR.
CONCLUSION:
This critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR literature. These knowledge gaps should be viewed as opportunities for improvement, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding.
401 citations
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TL;DR: To elucidate the efficacy, safety, and patient characteristics of responsiveness to mepolizumab (a humanized monoclonal antibody against interleukin 5), a large number of patients with severe, eosinophilic asthma were enrolled in 81 multinational centers.
Abstract: ID Pavord, S Korn, P Howarth. Lancet. 2012;380(9842):651–659
To elucidate the efficacy, safety, and patient characteristics of responsiveness to mepolizumab (a humanized monoclonal antibody against interleukin 5). Previous small, proof-of-concept studies in subjects with severe, eosinophilic asthma revealed that mepolizumab decreased exacerbation rates.
From 81 multinational centers, 621 pa-tients were enrolled. Major inclusion criteria included: age 12 to 74 years, asthma diagnosis with objective measures, ≥2 asthma exacerbations requiring oral corticosteroids in the last year, refractory asthma as defined by the American …
387 citations
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British Thoracic Society1, St James's University Hospital2, Barts Health NHS Trust3, Coventry Health Care4, Royal Surrey County Hospital5, North Bristol NHS Trust6, University of Bristol7, University Hospital of South Manchester NHS Foundation Trust8, Central Manchester University Hospitals NHS Foundation Trust9, University of Plymouth10, Guy's and St Thomas' NHS Foundation Trust11, Imperial College London12, Queen's University13, Royal College of Physicians14
TL;DR: Oxygen enrichment should be adjusted to achieve SaO2 88–92% in all causes of acute hypercapnic respiratory failure (AHRF) treated by NIV, and oxygen should be entrained as close to the patient as possible.
Abstract: ### Principles of mechanical ventilation
#### Modes of mechanical ventilation
Recommendation
1. Pressure-targeted ventilators are the devices of choice for acute NIV (Grade B).
Good practice points
#### Choice of interface for NIV
Recommendation
2. A full face mask (FFM) should usually be the first type of interface used (Grade D).
Good practice points
#### Indications for and contra-indications to NIV in AHRF
Recommendation
3. The presence of adverse features increase the risk of NIV failure and should prompt consideration of placement in high dependency unit (HDU)/intensive care unit (ICU) (Grade C).
Good practice points
#### Monitoring during NIV
Good practice points
#### Supplemental oxygen therapy with NIV
Recommendations
4. Oxygen enrichment should be adjusted to achieve SaO2 88–92% in all causes of acute hypercapnic respiratory failure (AHRF) treated by NIV (Grade A).
5. Oxygen should be entrained as close to the patient as possible (Grade C).
Good practice points
244 citations