S
Sirisha Potala
Researcher at Indian Institute of Technology Madras
Publications - 7
Citations - 189
Sirisha Potala is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Immunotoxin & Fusion Toxin. The author has an hindex of 6, co-authored 7 publications receiving 178 citations.
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Antibacterial activity of plants used in Indian herbal medicine
TL;DR: Potential use of these plants for developing new antibacterial compounds against pathogenic microorganisms is revealed and the presence of phytochemicals such as alkaloids, tannins, triterpenoids, steroids and glycosides in the extracts ofThese plants supports their traditional uses as medicinal plants for the treatment of various ailments.
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Targeted therapy of cancer using diphtheria toxin-derived immunotoxins
TL;DR: Continuous efforts are being made to investigate molecules exclusively expressed on cancer cells, to improve the specificity and efficacy of these immunotoxins, and to eliminate side effects and improve pharmacokinetics and ensure better drug delivery.
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Modified DT–IL2 fusion toxin targeting uniquely IL2Rα expressing leukemia cell lines – Construction and characterization
TL;DR: SPRSV2 exhibited potent cytotoxicity effectively targeted to alpha subunit of IL2R on various leukemia cell lines, and studies showed a negative correlation between CD25 expression and percentage cell viability after treatment with immunotoxins.
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Targeting head and neck squamous cell carcinoma using a novel fusion toxin-diphtheria toxin/HN-1
TL;DR: The fusion toxin DT/HN-1 demonstrated remarkably high degree of cytotoxicity specific to the HNSCC cells, establishing the importance of a ligand in achieving targeted toxicity.
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A Novel Fusion Protein Diphtheria Toxin–Stem Cell Factor (DT-SCF)—Purification and Characterization
TL;DR: This is the first study reporting specificity and efficacy of DT-SCF against tumor cells expressing c-kit against a range of malignancies such as chronic myeloid leukemia, acute lymphoblastic leukemia, pancreatic carcinoma, and cervical carcinoma.