S
Siru Mäkelä
Researcher at University of Helsinki
Publications - 28
Citations - 955
Siru Mäkelä is an academic researcher from University of Helsinki. The author has contributed to research in topics: Medicine & Melanoma. The author has an hindex of 8, co-authored 23 publications receiving 813 citations.
Papers
More filters
Journal ArticleDOI
Characterization of a common susceptibility locus for asthma-related traits
Tarja Laitinen,Anne Polvi,Pia Rydman,Johanna Vendelin,Ville Pulkkinen,Paula Salmikangas,Siru Mäkelä,Marko Rehn,Asta Pirskanen,Anna Rautanen,Marco Zucchelli,Harriet Gullstén,Harriet Gullstén,Marina Leino,Harri Alenius,Tuula Petäys,Tari Haahtela,Annika Laitinen,Catherine Laprise,Thomas J. Hudson,Lauri A. Laitinen,Juha Kere,Juha Kere +22 more
TL;DR: In three cohorts from Finland and Canada, single nucleotide polymorphism–tagged haplotypes associated with high serum immunoglobulin E or asthma or asthma implicate GPRA in the pathogenesis of atopy and asthma.
Journal ArticleDOI
Discontinuation of anti-PD-1 antibody therapy in the absence of disease progression or treatment limiting toxicity: clinical outcomes in advanced melanoma
Y.J.L. Jansen,Elisa A. Rozeman,Robert Mason,Simone M. Goldinger,M.H. Geukes Foppen,Lise Hoejberg,Henrik Schmidt,J.V. van Thienen,J.B.A.G. Haanen,Leena Tiainen,Inge Marie Svane,Siru Mäkelä,Teofila Seremet,A. Arance,Reinhard Dummer,Lars Bastholt,Marta Nyakas,Oddbjørn Straume,Alexander M. Menzies,Alexander M. Menzies,Georgina V. Long,Georgina V. Long,Victoria Atkinson,Christian U. Blank,Bart Neyns +24 more
TL;DR: In this real-world cohort of advanced melanoma patients discontinuing anti- PD-1 therapy in the absence of TLT or PD, the duration of anti-PD-1 Therapy was shorter when compared to clinical trials.
Journal ArticleDOI
SLC26A3 mutations in congenital chloride diarrhea
TL;DR: A summary of all published and two novel SLC26A3 mutations and polymorphisms are presented, and they are reviewed in the context of their functional consequences and clinical implications.
Journal ArticleDOI
Upregulation of CFTR expression but not SLC26A3 and SLC9A3 in ulcerative colitis
Hannes Lohi,Siru Mäkelä,Kari Pulkkinen,Pia Höglund,Marja-Liisa Karjalainen-Lindsberg,Pauli Puolakkainen,Juha Kere +6 more
TL;DR: Intestinal inflammation modulates the expression of three major mediators of intestinal salt transport and may contribute to diarrhea in ulcerative colitis both by increasing transepithelial Cl- secretion and by inhibiting the epithelial NaCl absorption.
Journal ArticleDOI
Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure.
TL;DR: It is concluded that the SLC26A8 mutations are not a common cause of male infertility, and none of them may be causally associated with infertility.