S
Sisu Han
Researcher at Sunnybrook Research Institute
Publications - 5
Citations - 90
Sisu Han is an academic researcher from Sunnybrook Research Institute. The author has contributed to research in topics: Proneural genes & Neurogenesis. The author has an hindex of 3, co-authored 5 publications receiving 50 citations. Previous affiliations of Sisu Han include Alberta Children's Hospital & University of Toronto.
Papers
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Journal ArticleDOI
Neurog2 and Ascl1 together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex.
Daniel J. Dennis,Grey Wilkinson,Saiqun Li,Rajiv Dixit,Lata Adnani,Anjali Balakrishnan,Sisu Han,Sisu Han,Christopher P. Kovach,Nicole Gruenig,Deborah M. Kurrasch,Richard H. Dyck,Carol Schuurmans +12 more
TL;DR: It is revealed that the proneural genes Neurog2 and Ascl1, which are together expressed in neocortical progenitors, cooperate to regulate the expression of components of the cortical derepression circuit to specify corticothalamic and subcerebral identities while repressing a callosal fate.
Book ChapterDOI
Mechanisms of Cortical Differentiation.
Lata Adnani,Sisu Han,Saiqun Li,Pierre Mattar,Carol Schuurmans,Carol Schuurmans,Carol Schuurmans +6 more
TL;DR: Current understanding of the intrinsic cues and environmental signals that govern cell fate specification and differentiation decisions during development of neuronal and glial lineages in the murine neocortex are reviewed.
Journal ArticleDOI
New Insights Into the Intricacies of Proneural Gene Regulation in the Embryonic and Adult Cerebral Cortex
TL;DR: In this article, a review of the regulatory properties of proneural genes encoding basic-helix-loophelix (bHLH) transcription factors (TFs) is presented, focusing on the murine cerebral cortex.
Journal ArticleDOI
Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding.
Sisu Han,Sisu Han,Satoshi Okawa,Grey Wilkinson,Hussein Ghazale,Hussein Ghazale,Lata Adnani,Lata Adnani,Rajiv Dixit,Rajiv Dixit,Lígia Tavares,Imrul Faisal,Imrul Faisal,Matthew Brooks,Veronique Cortay,Dawn Zinyk,Adam Sivitilli,Saiqun Li,Faizan Malik,Yaroslav Ilnytskyy,Vladimir Espinosa Angarica,Jinghua Gao,Jinghua Gao,Vorapin Chinchalongporn,Vorapin Chinchalongporn,Ana-Maria Oproescu,Ana-Maria Oproescu,Lakshmy Vasan,Lakshmy Vasan,Yacine Touahri,Yacine Touahri,Luke Ajay David,Luke Ajay David,Eko Raharjo,Jung-Woong Kim,Wei Wu,Waleed Rahmani,Jennifer A. Chan,Igor Kovalchuk,Liliana Attisano,Deborah M. Kurrasch,Colette Dehay,Anand Swaroop,Diogo S. Castro,Jeff Biernaskie,Antonio del Sol,Antonio del Sol,Carol Schuurmans +47 more
TL;DR: This article found that double+ NPCs are Notch-ligand-expressing "niche" cells that control neurogenic periodicity and cortical folding in mouse and human cerebral organoids.
Posted ContentDOI
Proneural genes define ground state rules to regulate neurogenic patterning and cortical folding
Sisu Han,Sisu Han,Grey Wilkinson,Satoshi Okawa,Lata Adnani,Lata Adnani,Rajiv Dixit,Imrul Faisal,Imrul Faisal,Matthew Brooks,Veronique Cortay,Vorapin Chinchalongporn,Dawn Zinyk,Saiqun Li,Jinghua Gao,Jinghua Gao,Faizan Malik,Yacine Touahri,Vladimir Espinosa Angarica,Ana-Maria Oproescu,Ana-Maria Oproescu,Eko Raharjo,Yaroslav Ilnytskyy,Jung-Woong Kim,Wei Wu,Waleed Rahmani,Igor Kovalchuk,Jennifer A. Chan,Deborah M. Kurrasch,Diogo S. Castro,Colette Dehay,Anand Swaroop,Jeff Biernaskie,Antonio del Sol,Carol Schuurmans +34 more
TL;DR: It is shown that Neurog2 and Ascl1 proneural genes regulate cortical progenitor cell differentiation through cross-repressive interactions to sustain neurogenic continuity in a lissencephalic rodent brain.