S
Siyuan Shen
Researcher at University of Science and Technology of China
Publications - 3
Citations - 34
Siyuan Shen is an academic researcher from University of Science and Technology of China. The author has contributed to research in topics: RNA recognition motif & RNA splicing. The author has an hindex of 1, co-authored 3 publications receiving 9 citations.
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Journal ArticleDOI
ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8.
S. Chul Kwon,S. Chul Kwon,Harim Jang,Siyuan Shen,S. Chan Baek,Kijun Kim,Jihye Yang,Jeesoo Kim,Jong-Seo Kim,Suman Wang,Yunyu Shi,Fudong Li,V. Narry Kim +12 more
TL;DR: The study reveals a role of ERH in the miRNA biogenesis pathway and reveals that the ERH dimer may mediate ‘cluster assistance’ in which Microprocessor is loaded onto a poor substrate with help from a high-affinity substrate in the same cluster.
Journal ArticleDOI
Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing.
Saikat Bhattacharya,Suman Wang,Divya Reddy,Siyuan Shen,Ying Zhang,Ning Zhang,Hua Li,Michael P. Washburn,Laurence Florens,Yunyu Shi,Jerry L. Workman,Fudong Li +11 more
TL;DR: In this article, the authors describe the mode of interaction between hnRNP L and LL with the methyltransferase SETD2 and demonstrate that for the interaction to occur, a leucine pair within a highly conserved stretch of SetD2 insert their side chains in hydrophobic pockets formed by hnRN L RRM2.
Posted ContentDOI
Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing
Saikat Bhattacharya,Suman Wang,Divya Reddy,Siyuan Shen,Ying Zhang,Ning Zhang,Hua Li,Michael P. Washburn,Laurence Florens,Yunyu Shi,Fudong Li,Jerry L. Workman +11 more
TL;DR: In this article, the authors describe the mode of interaction between hnRNP L and LL with the methyltransferase SETD2 and demonstrate that for the interaction to occur, a leucine pair within a highly conserved stretch of SetD2 insert their side chains in hydrophobic pockets formed by hnRN L RRM2.