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So Yeon Kong

Bio: So Yeon Kong is an academic researcher from International Agency for Research on Cancer. The author has contributed to research in topics: European Prospective Investigation into Cancer and Nutrition & Cancer. The author has an hindex of 7, co-authored 7 publications receiving 306 citations.

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TL;DR: The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women.
Abstract: Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring seru ...

155 citations

Journal ArticleDOI
TL;DR: The results support the idea that individuals with the metabolically healthy/overweight phenotype (with normal insulin levels) are at lower colorectal cancer risk than those with hyperinsulinaemia.
Abstract: The coordination of EPIC is financially supported by the European Commission (DGSANCO); and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer; Institut Gustave Roussy; Mutuelle Generale de l’Education Nationale; and Institut National de la Sante et de la Recherche Medicale (INSERM) (France); Deutsche Krebshilfe, Deutsches Krebsforschungszentrum; and Federal Ministry of Education and Research (Germany); Hellenic Health Foundation; Stavros Niarchos Foundation; and the Hellenic Ministry of Health and Social Solidarity (Greece); Italian Association for Research on Cancer (AIRC); National Research Council; and Associazione Iblea per la Ricerca Epidemiologica (AIRE-ONLUS) Ragusa, Associazione Volontari Italiani Sangu (AVIS) Ragusa, Sicilian Government (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS); Netherlands Cancer Registry (NKR); LK Research Funds; Dutch Prevention Funds; Dutch ZON (Zorg Onderzoek Nederland); World Cancer Research Fund (WCRF); and Statistics Netherlands (the Netherlands); European Research Council (ERC) (grant number ERC-2009-AdG 232997) and Nordforsk; and Nordic Center of Excellence Programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS); Regional Governments of Andalucia, Asturias, Basque Country, Murcia (No. 6236) and Navarra; and the Centro de Investigacion Biomedica en Red en Epidemiologia y Salud Publica and Instituto de Salud Carlos II (ISCIII RETIC) (RD06/ 0020) (Spain); Swedish Cancer Society; Swedish Scientific Council; and Regional Government of Skane and Vasterbotten (Sweden); Cancer Research UK; Medical Research Council; Stroke Association; British Heart Foundation; Department of Health; Food Standards Agency; Wellcome Trust (UK); and National Cancer Institute (USA) (grant number: 1RO1CA102460) (PI, Professor Rudolf Kaaks). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

83 citations

Journal ArticleDOI
TL;DR: The results of this study do not support LTL as a uniform and strong predictor of pancreatic cancer risk and can provide insights into telomere dynamics and highlight the complex relationship between LTL and Pancreas cancer risk.
Abstract: Background: Several studies have examined leukocyte telomere length (LTL) as a possible predictor for cancer at various organ sites. The hypothesis originally motivating many of these studies was that shorter telomeres would be associated with an increase in cancer risk, the results of epidemiologic studies have been inconsistent, however, and suggested positive, negative, or null associations. Two studies have addressed the association of LTL in relation to pancreatic cancer risk and the results are contrasting. Methods: we measured LTL in a prospective study of 331 pancreatic cancer cases and 331 controls in the context of the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: We observed that the mean LTL was higher in cases (0.59±0.20) than in controls (0.57±0.17), although this difference was not statistically significant (p=0.07), and a basic logistic regression model showed no association of LTL with pancreas cancer risk. When adjusting for levels of HbA1c and C-Peptide, however, there was a weakly positive association between longer LTL and pancreatic cancer risk , OR=1.13 (1.01-1.27). Additional analyses by cubic spline regression suggested a possible non-linear relationship between RTL and pancreatic cancer risk (P=0.022), with a statistically non-significant increase in risk at very low LTL, as well as a significant increase at high LTL. Conclusion: Taken together, the results from our study do not support LTL as a uniform and strong predictor of pancreatic cancer. Impact: The results of this manuscript can provide insights into telomere dynamics and highlight the complex relationship between LTL and pancreatic cancer risk.

38 citations

Journal ArticleDOI
TL;DR: The prediagnostic reported intake of dairy products and dietary calcium is not associated with disease-specific or all-cause risk of death in patients diagnosed with colorectal cancer.
Abstract: Background We investigated whether prediagnostic reported intake of dairy products and dietary calcium are associated with colorectal cancer (CRC) survival. Methods Data from 3,859 subjects with CRC (42.1% male, mean age at diagnosis 64.2 ± 8.1 years) in the European Investigation into Cancer and Nutrition (EPIC) cohort were analyzed. Intake of dairy products and dietary calcium was assessed at baseline (1992-2000) using validated, country-specific dietary questionnaires. Multivariable Cox regression models were used to calculate hazard ratios (HR) and corresponding 95% confidence intervals (95%-CI) for CRC specific death (n=1,028) and all-cause death (n=1,525) for different quartiles of intake. Results The consumption of total dairy products was not statistically significantly associated with risk of CRC-specific death (adjusted HR Q4 vs. Q1: 1.17 95%-CI 0.97-1.43) nor of all-cause death (Q4 vs. Q1: 1.16 95%-CI 0.98-1.36). Multivariable adjusted HRs for CRC-specific death (Q4 vs. Q1) were 1.21 (95%-CI 0.99-1.48) for milk, 1.09 (95%-CI 0.88-1.34) for yoghurt and 0.93 (95%-CI 0.76-1.14) for cheese. The intake of dietary calcium was not associated with the risk of CRC-specific (adjusted HR Q4 vs. Q1: 1.01 95%-CI 0.81-1.26) nor of all-cause death (Q4 vs. Q1: 1.01 95%-CI 0.84-1.21). Conclusions The prediagnostic reported intake of dairy products and dietary calcium are not associated with disease-specific or all-cause risk of death in patients diagnosed with CRC. Impact The impact of diet on cancer survival is largely unknown. This study shows that despite it's inverse association with CRC risk, the prediagnostic intake of dairy and dietary calcium do not affect CRC survival.

34 citations

Journal ArticleDOI
TL;DR: A large proportion of colorectal cancers are associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, and hypergly....
Abstract: Background: A large proportion of colorectal cancers are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, and hypergly ...

31 citations


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924 citations

Gloria M. Petersen1, Laufey T. Amundadottir2, Charles S. Fuchs3, Peter Kraft3, Rachael Z. Stolzenberg-Solomon2, Kevin B. Jacobs2, Kevin B. Jacobs4, Alan A. Arslan5, H. Bas Bueno-de-Mesquita6, Steven Gallinger7, Myron D. Gross8, Kathy J. Helzlsouer9, Elizabeth A. Holly10, Eric J. Jacobs11, Alison P. Klein12, Andrea Z. LaCroix13, Donghui Li14, Margaret T. Mandelson13, Sara H. Olson14, Harvey A. Risch15, Wei Zheng16, Demetrius Albanes2, William R. Bamlet1, Christine D. Berg2, Marie-Christine Boutron-Ruault17, Julie E. Buring3, Paige M. Bracci10, Federico Canzian18, Sandra Clipp12, Michelle Cotterchio7, Mariza de Andrade1, Eric J. Duell, J. Michael Gaziano3, J. Michael Gaziano19, Edward Giovannucci3, Michael Goggins12, Göran Hallmans20, Susan E. Hankinson3, Manal Hassan14, Barbara V. Howard21, David J. Hunter3, Amy K. Hutchinson2, Amy K. Hutchinson4, Mazda Jenab, Rudolf Kaaks18, Charles Kooperberg13, Vittorio Krogh, Robert C. Kurtz22, Shannon M. Lynch2, Robert R. McWilliams1, Julie B. Mendelsohn2, Dominique S. Michaud22, Dominique S. Michaud3, Hemang Parikh2, Alpa V. Patel11, Petra H.M. Peeters22, Petra H.M. Peeters6, Aleksandar Rajkovic23, Elio Riboli24, Laudina Rodríguez, Daniela Seminara2, Xiao-Ou Shu16, Gilles Thomas25, Gilles Thomas2, Anne Tjønneland, Geoffrey S. Tobias2, Dimitrios Trichopoulos3, Dimitrios Trichopoulos26, Stephen K. Van Den Eeden27, Jarmo Virtamo28, Jean Wactawski-Wende29, Zhaoming Wang4, Zhaoming Wang2, Brian M. Wolpin3, Herbert Yu15, Kai Yu2, Anne Zeleniuch-Jacquotte5, Joseph F. Fraumeni2, Robert N. Hoover2, Patricia Hartge2, Stephen J. Chanock22, Stephen J. Chanock30, Stephen J. Chanock2 
01 Jan 2010
TL;DR: This study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies and identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.1 that are associated with multiple cancers.
Abstract: We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.

494 citations

Journal ArticleDOI
TL;DR: Diet modification has the promise of reducing colorectal cancer incidence and emerging evidence also implicates the gut microbiota as an important effector in the relationship between diet and cancer.

466 citations

Journal ArticleDOI
TL;DR: Findings have limitations due to study design, quality and heterogeneity that complicate interpretation of the summary statistics, and some studies suggested that genetic factors may modify the relation between selenium and cancer risk-a hypothesis that deserves further investigation.
Abstract: Background This review is an update of the first Cochrane publication on selenium for preventing cancer (Dennert 2011). Selenium is a metalloid with both nutritional and toxicological properties. Higher selenium exposure and selenium supplements have been suggested to protect against several types of cancers.

455 citations