S
Soh Leh Kuan
Researcher at University of Aberdeen
Publications - 3
Citations - 4857
Soh Leh Kuan is an academic researcher from University of Aberdeen. The author has contributed to research in topics: Transgene & Epigenetics of schizophrenia. The author has an hindex of 3, co-authored 3 publications receiving 4448 citations.
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Journal ArticleDOI
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
Shaun Purcell,Shaun Purcell,Naomi R. Wray,Jennifer Stone,Jennifer Stone,Peter M. Visscher,Michael Conlon O'Donovan,Patrick F. Sullivan,Pamela Sklar,Pamela Sklar,Douglas M. Ruderfer,Andrew McQuillin,Derek W. Morris,Colm O'Dushlaine,Aiden Corvin,Peter Holmans,Stuart MacGregor,Hugh Gurling,Douglas Blackwood,Nicholas John Craddock,Michael Gill,Christina M. Hultman,Christina M. Hultman,George Kirov,Paul Lichtenstein,Walter J. Muir,Michael John Owen,Carlos N. Pato,Edward M. Scolnick,Edward M. Scolnick,David St Clair,Nigel Williams,Lyudmila Georgieva,Ivan Nikolov,Nadine Norton,Hywel Williams,Draga Toncheva,Vihra Milanova,Emma Flordal Thelander,Patrick Sullivan,Elaine Kenny,Emma M. Quinn,Khalid Choudhury,Susmita Datta,Jonathan Pimm,Srinivasa Thirumalai,Vinay Puri,Robert Krasucki,Jacob Lawrence,Digby Quested,Nicholas Bass,Caroline Crombie,Gillian Fraser,Soh Leh Kuan,Nicholas Walker,Kevin A. McGhee,Ben S. Pickard,P. Malloy,Alan W Maclean,Margaret Van Beck,Michele T. Pato,Helena Medeiros,Frank A. Middleton,Célia Barreto Carvalho,Christopher P. Morley,Ayman H. Fanous,David V. Conti,James A. Knowles,Carlos Ferreira,António Macedo,M. Helena Azevedo,Andrew Kirby,Andrew Kirby,Manuel A. R. Ferreira,Manuel A. R. Ferreira,Mark J. Daly,Mark J. Daly,Kimberly Chambert,Finny G Kuruvilla,Stacey Gabriel,Kristin G. Ardlie,Jennifer L. Moran +81 more
TL;DR: The extent to which common genetic variation underlies the risk of schizophrenia is shown, using two analytic approaches, and the major histocompatibility complex is implicate, which is shown to involve thousands of common alleles of very small effect.
Journal ArticleDOI
Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing Truncated Disc1
Sanbing Shen,Bing Lang,Chizu Nakamoto,Feng Zhang,Jin Pu,Soh Leh Kuan,Christina Chatzi,Shuisheng He,Iain Mackie,Nicholas J. Brandon,Karen L. Marquis,Mark Day,Orest Hurko,Orest Hurko,Colin D. McCaig,Gernot Riedel,David St Clair +16 more
TL;DR: Disrupted-in-Schizophrenia-1 transgenic mice exhibit increased immobility and reduced vocalization in depression-related tests, and impairment in conditioning of latent inhibition, consistent with findings in severe schizophrenia.
Journal ArticleDOI
In vitro guidance of retinal axons by a tectal lamina-specific glycoprotein Nel.
Yulan Jiang,Hiroya Obama,Hiroya Obama,Soh Leh Kuan,Ritsuko Nakamura,Ritsuko Nakamura,Ritsuko Nakamura,Chizu Nakamoto,Zhufeng Ouyang,Zhufeng Ouyang,Masaru Nakamoto,Masaru Nakamoto,Masaru Nakamoto +12 more
TL;DR: Results indicate that Nel acts as an inhibitory guidance cue for retinal axons, and suggest its roles in the establishment of the lamina-specificity in the retinotectal projection.