S
Soheila Rahgozar
Researcher at University of Isfahan
Publications - 72
Citations - 1526
Soheila Rahgozar is an academic researcher from University of Isfahan. The author has contributed to research in topics: Minimal residual disease & Drug resistance. The author has an hindex of 17, co-authored 67 publications receiving 1243 citations. Previous affiliations of Soheila Rahgozar include St George's Hospital & Tarbiat Modares University.
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Current concepts on the pathogenesis of the antiphospholipid syndrome.
TL;DR: This review critically examines the experimental evidence underlying the various propositions made to explain how antiphospholipid antibodies may predispose to disease in humans and examines the evidence relating to the immunologic mechanisms that may contribute to the breakage of peripheral tolerance in this disorder.
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Iron oxide nanoparticles may damage to the neural tissue through iron accumulation, oxidative stress, and protein aggregation
TL;DR: IONPs depending on their properties can lead to iron accumulation, oxidative stress and protein aggregation in the neural cells, which can be toxic for the cell.
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Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans.
Nabil Enattah,Aimee Trudeau,Ville Pimenoff,Luigi Maiuri,Salvatore Auricchio,Luigi Greco,Mauro Rossi,Michael J. Lentze,J.K. Seo,Soheila Rahgozar,Insaf F. Khalil,Michael Alifrangis,Sirajedin S. Natah,Leif Groop,Nael Shaat,Andrew Kozlov,Galina Verschubskaya,David Comas,Kazima B. Bulayeva,S. Qasim Mehdi,Joseph D. Terwilliger,Timo Sahi,Erkki Savilahti,Markus Perola,Antti Sajantila,Irma Järvelä,Leena Peltonen +26 more
TL;DR: The data about global allelic haplotypes of the lactose-tolerance variant imply that the T(-13910) allele has been independently introduced more than once and that there is a still-ongoing process of convergent evolution of the LP alleles in humans.
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Naturally occurring free thiols within β2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress–induced cell injury
Yiannis Ioannou,Yiannis Ioannou,Jing-Yun Zhang,Jing-Yun Zhang,Freda Passam,Soheila Rahgozar,Jian Cheng Qi,Bill Giannakopoulos,M. Qi,Pei Yu,Pei Yu,Demin M. Yu,Philip J. Hogg,Steven A. Krilis +13 more
TL;DR: The functional significance of these findings is explored, by showing that free thiol-containing β2GPI has a powerful effect in protecting endothelial cells and EAhy926 cells from oxidative stress-induced cell death.
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Beta 2 glycoprotein I is a substrate of thiol oxidoreductases.
Freda Passam,Soheila Rahgozar,Miao Qi,Mark J. Raftery,Jason W. H. Wong,Kumiko Tanaka,Yiannis Ioannou,Jing Yun Zhang,Rosalie Gemmell,Jian Chen Qi,Bill Giannakopoulos,William E. Hughes,Philip J. Hogg,Steven A. Krilis +13 more
TL;DR: The β2GPI is an abundant plasma protein recognized as the major autoantigen in the antiphospholipid syndrome as mentioned in this paper, but its normal function remains unknown.