S
Solbritt Rantapää-Dahlqvist
Researcher at Umeå University
Publications - 252
Citations - 19637
Solbritt Rantapää-Dahlqvist is an academic researcher from Umeå University. The author has contributed to research in topics: Rheumatoid arthritis & Arthritis. The author has an hindex of 61, co-authored 220 publications receiving 17625 citations. Previous affiliations of Solbritt Rantapää-Dahlqvist include Linköping University & Karolinska University Hospital.
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Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis.
Solbritt Rantapää-Dahlqvist,Ben A. W. de Jong,Ewa Berglin,Göran Hallmans,Göran Wadell,Hans Stenlund,Ulf Sundin,Walther J. van Venrooij +7 more
TL;DR: Anti-CCP antibody and RFs of all isotypes predated the onset of RA by several years, indicating that citrullination and the production of anti- CCP and RF autoantibodies are early processes in RA.
Journal ArticleDOI
A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.
Lars Klareskog,Patrik Stolt,Karin Lundberg,Henrik Källberg,Camilla Bengtsson,Johan Grunewald,Johan Rönnelid,Helena Erlandsson Harris,Ann-Kristin Ulfgren,Solbritt Rantapää-Dahlqvist,Anders Eklund,Leonid Padyukov,Lars Alfredsson +12 more
TL;DR: An etiology involving a specific genotype, an environmental provocation, and the induction of specific autoimmunity are suggested, all restricted to a distinct subset of RA.
Journal ArticleDOI
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
Geoffrey Hom,Robert R. Graham,Barmak Modrek,Kimberly E. Taylor,Ward Ortmann,Sophie Garnier,Annette Lee,Sharon A. Chung,Ricardo C. Ferreira,P. V. Krishna Pant,Dennis G. Ballinger,Roman Kosoy,F. Yesim Demirci,M. Ilyas Kamboh,Amy H. Kao,Chao Tian,Iva Gunnarsson,Anders A. Bengtsson,Solbritt Rantapää-Dahlqvist,Michelle Petri,Susan Manzi,Michael F. Seldin,Lars Rönnblom,Ann-Christine Syvänen,Lindsey A. Criswell,Peter K. Gregersen,Timothy W. Behrens +26 more
TL;DR: The authors identified and then confirmed through replication two new genetic loci for SLE: a promoter-region allele associated with reduced expression of BLK and increased expression of C8orf13 and variants in the ITGAM-ITGAX region.
Journal ArticleDOI
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
Vesela Gateva,Johanna K. Sandling,Geoff Hom,Kimberly E. Taylor,Sharon A. Chung,Xin Sun,Ward Ortmann,Roman Kosoy,Ricardo C. Ferreira,Gunnel Nordmark,Iva Gunnarsson,Elisabet Svenungsson,Leonid Padyukov,Gunnar Sturfelt,Andreas Jönsen,Anders A. Bengtsson,Solbritt Rantapää-Dahlqvist,Emily C. Baechler,Elizabeth E. Brown,Graciela S. Alarcón,Jeffrey C. Edberg,Rosalind Ramsey-Goldman,Gerald McGwin,John D. Reveille,Luis M. Vilá,Robert P. Kimberly,Susan Manzi,Michelle Petri,Annette Lee,Peter K. Gregersen,Michael F. Seldin,Lars Rönnblom,Lindsey A. Criswell,Ann-Christine Syvänen,Timothy W. Behrens,Robert R. Graham +35 more
TL;DR: The results expand the number of confirmed and candidate SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis.