Solène Brelle

TL;DR: It is demonstrated that VraR can be phosphorylated by the staphylococcal Ser/Thr protein kinase Stk1 and that phosphorylation negatively affects its DNA-binding properties, enabling convergence of two major signal transduction systems, serine/threonineprotein kinase and two (three)-component systems.

TL;DR: It is demonstrated that SpoVG can be phosphorylated by the staphylococcal Ser/Thr protein kinase Stk1 and that phosphorylation positively affects its DNA-binding properties and the expression/activity of this transcription factor is tightly controlled in S. aureus by transcriptional, post-transcriptional and post- translational mechanisms.

TL;DR: PtpA is an exported S. aureus signaling molecule controlled by tyrosine phosphorylation which may interfere with host cell signaling, and the observation that CapA1B2-mediatedosphorylation significantly increased PtpA phosphatase activity is provided.

TL;DR: The results indicate that CstK functions as a bacterial effector protein that interacts with the host protein TBC1D5 during vacuole biogenesis and intracellular replication.

TL;DR: The results indicate that CstK has a critical role during infection as a bacterial effector protein that interacts with host proteins to facilitate vacuole biogenesis and intracellular replication.