S
Solveig K. Sieberts
Researcher at Sage Bionetworks
Publications - 62
Citations - 6704
Solveig K. Sieberts is an academic researcher from Sage Bionetworks. The author has contributed to research in topics: Genome-wide association study & Expression quantitative trait loci. The author has an hindex of 24, co-authored 57 publications receiving 5479 citations. Previous affiliations of Solveig K. Sieberts include Icahn School of Medicine at Mount Sinai & Merck & Co..
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Journal ArticleDOI
An integrative genomics approach to infer causal associations between gene expression and disease
Eric E. Schadt,John Lamb,Xia Yang,Jun Zhu,Steve Edwards,Debraj GuhaThakurta,Solveig K. Sieberts,Stephanie A. Monks,Marc L. Reitman,Chunsheng Zhang,Pek Yee Lum,Amy Leonardson,Rolf Thieringer,Joseph M. Metzger,Liming Yang,John C. Castle,Haoyuan Zhu,Shera F Kash,Thomas A. Drake,Alan B. Sachs,Aldons J. Lusis +20 more
TL;DR: It is shown that this approach can predict transcriptional responses to single gene–perturbation experiments using gene-expression data in the context of a segregating mouse population and the utility of this approach is demonstrated by identifying and experimentally validating the involvement of three new genes in susceptibility to obesity.
Journal ArticleDOI
Mapping the Genetic Architecture of Gene Expression in Human Liver
Eric E. Schadt,Cliona Molony,Eugene Chudin,Ke-Ke Hao,Xia Yang,Pek Yee Lum,Andrew Kasarskis,Bin Zhang,Susanna Wang,Christine Suver,Jun Zhu,Joshua Millstein,Solveig K. Sieberts,John Lamb,Debraj GuhaThakurta,Jonathan M. J. Derry,John D. Storey,Iliana Avila-Campillo,Mark J Kruger,Jason M. Johnson,Carol A. Rohl,Atila van Nas,Margarete Mehrabian,Thomas A. Drake,Aldons J. Lusis,Ryan Smith,F. Peter Guengerich,Stephen C. Strom,Erin G. Schuetz,Thomas H. Rushmore,Roger G. Ulrich +30 more
TL;DR: This genome-wide association study of gene expression resulted in the detection of more than 6,000 associations between SNP genotypes and liver gene expression traits, where many of the corresponding genes identified have already been implicated in a number of human diseases.
Journal ArticleDOI
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Menachem Fromer,Panos Roussos,Solveig K. Sieberts,Jessica S. Johnson,David H. Kavanagh,Thanneer M. Perumal,Douglas M. Ruderfer,Edwin C. Oh,Aaron Topol,Hardik Shah,Lambertus Klei,Robin Kramer,Dalila Pinto,Zeynep H. Gümüş,A. Ercument Cicek,Kristen K. Dang,Andrew W. Browne,Cong Lu,Lu Xie,Ben Readhead,Eli A. Stahl,Jianqiu Xiao,Mahsa Parvisi,Tymor Hamamsy,John F. Fullard,Ying-Chih Wang,Milind Mahajan,Jonathan M. J. Derry,Joel T. Dudley,Scott E. Hemby,Benjamin A. Logsdon,Konrad Talbot,Towfique Raj,Towfique Raj,David A. Bennett,Philip L. De Jager,Philip L. De Jager,Jun Zhu,Bin Zhang,Patrick F. Sullivan,Patrick F. Sullivan,Andrew Chess,Shaun Purcell,Leslie A. Shinobu,Lara M. Mangravite,Hiroyoshi Toyoshiba,Raquel E. Gur,Chang-Gyu Hahn,David A. Lewis,Vahram Haroutunian,Mette A. Peters,Barbara K. Lipska,Joseph D. Buxbaum,Eric E. Schadt,Keisuke Hirai,Kathryn Roeder,Kristen J. Brennand,Nicholas Katsanis,Enrico Domenici,Bernie Devlin,Pamela Sklar +60 more
TL;DR: It is shown that schizophrenia is polygenic and the utility of this resource of gene expression and its genetic regulation for mechanistic interpretations of genetic liability for brain diseases is highlighted.
Journal ArticleDOI
Variations in DNA elucidate molecular networks that cause disease
Yanqing Chen,Jun Zhu,Pek Yee Lum,Xia Yang,Shirly Pinto,Douglas J. MacNeil,Chunsheng Zhang,John Lamb,Stephen W. Edwards,Solveig K. Sieberts,Amy Leonardson,Lawrence W. Castellini,Susanna Wang,Marie-France Champy,Bin Zhang,Valur Emilsson,Sudheer Doss,Anatole Ghazalpour,Steve Horvath,Thomas A. Drake,Aldons J. Lusis,Eric E. Schadt +21 more
TL;DR: Application of this method to liver and adipose gene expression data generated from a segregating mouse population results in the identification of a macrophage-enriched network supported as having a causal relationship with disease traits associated with metabolic syndrome.
Journal ArticleDOI
An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome.
Bernard Ng,Charles C. White,Hans-Ulrich Klein,Hans-Ulrich Klein,Solveig K. Sieberts,Cristin McCabe,Ellis Patrick,Jishu Xu,Lei Yu,Chris Gaiteri,David A. Bennett,Sara Mostafavi,Sara Mostafavi,Philip L. De Jager,Philip L. De Jager +14 more
TL;DR: A multi-omic resource generated by applying quantitative trait locus (xQTL) analyses to RNA sequence, DNA methylation and histone acetylation data from the dorsolateral prefrontal cortex of 411 older adults who have all three data types is reported.