S
Somnath Singha Roy
Researcher at Chittaranjan National Cancer Institute
Publications - 21
Citations - 634
Somnath Singha Roy is an academic researcher from Chittaranjan National Cancer Institute. The author has contributed to research in topics: Oxidative stress & Lipid peroxidation. The author has an hindex of 14, co-authored 21 publications receiving 527 citations. Previous affiliations of Somnath Singha Roy include Sanjay Gandhi Post Graduate Institute of Medical Sciences.
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Journal ArticleDOI
Unveiling the groove binding mechanism of a biocompatible naphthalimide-based organoselenocyanate with calf thymus DNA: an "ex vivo" fluorescence imaging application appended by biophysical experiments and molecular docking simulations
Soumya Sundar Mati,Somnath Singha Roy,Sayantani Chall,Sudin Bhattacharya,Subhash Chandra Bhattacharya +4 more
TL;DR: Experimental results based on spectroscopy, isothermal calorimetry, electrochemistry aided with DNA-melting, and circular dichroism studies unambiguously established the formation of a groove binding network between the NPOS and ctDNA.
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Tunable solvatochromic response of newly synthesized antioxidative naphthalimide derivatives: intramolecular charge transfer associated with hydrogen bonding effect.
Sayaree Dhar,Somnath Singha Roy,Dipak Kumar Rana,Sudin Bhattacharya,Sumanta Bhattacharya,Subhash Chandra Bhattacharya +5 more
TL;DR: The solvatochromic behavior of two newly synthesized naphthalimide derivatives (I and II) which have potential antioxidative activities in anticarcinogenic drug development treatment, has been monitored in protic and aprotic solvents of different polarity applying steady-state and time-resolved fluorescence techniques.
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Catalyst-Free “On-Water” Regio- and Stereospecific Ring-Opening of Spiroaziridine Oxindole: Enantiopure Synthesis of Unsymmetrical 3,3′-Bisindoles
TL;DR: This method provides direct access to enantiopure 3,3'-mixed bisindoles with excellent yield and enantioselectivity (up to 98% ee).
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Naphthalimide based novel organoselenocyanates: finding less toxic forms of selenium that would retain protective efficacy.
Somnath Singha Roy,Prosenjit Ghosh,Ugir Hossain Sk,Pramita Chakraborty,Jaydip Biswas,Syamsundar Mandal,Arin Bhattacharjee,Sudin Bhattacharya +7 more
TL;DR: A series of naphthalimide based organoselenocyanates were synthesized and screened for their toxicity as well as their ability to modulate several detoxifying/antioxidative enzyme levels at a primary screening dose of 3 mg/kg b.w. in normal Swiss albino mice for 30 days.
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Attenuation of doxorubicin-induced cardiotoxicity and genotoxicity by an indole-based natural compound 3,3'-diindolylmethane (DIM) through activation of Nrf2/ARE signaling pathways and inhibiting apoptosis.
TL;DR: It is suggested that DIM has promising chemoprotective efficacy against DOX-induced toxicity and indicates its future use as an adjuvant in chemotherapy.