Song Lei

Bio: Song Lei is an academic researcher from Jiangsu Normal University. The author has contributed to research in topics: Aryl & Ionic liquid. The author has an hindex of 3, co-authored 7 publications receiving 90 citations.

A Facile One‐Pot Three‐Component Synthesis of 5‐(Trifluoromethyl)‐4,7‐dihydro‐[1,2,4]‐triazolo[1,5‐a]pyrimidine Derivatives in Ionic Liquid

Abstract: An efficient one-pot synthesis of 5-(trifluoromethyl)-4,7-dihydro-7-aryl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives was performed via the reaction of aryl aldehyde, 3-amino-1,2,4-triazole and ethyl 4,4,4-trifluoro-3-oxobutanoate or 4,4,4-trifluoro-1-phenylbutane-1,3-dione in ionic liquid. This method has the advantages of short synthetic route, operational simplicities, mild reaction conditions, high yields and eco-friendliness.

Solvent‐Free Synthesis of 5‐Methyl‐7‐aryl‐4,7‐dihydrotetrazolo[1,5‐a]pyrimidine‐6‐carboxylic Esters Catalyzed by Sulfamic Acid.

Abstract: The solvent-free synthesis of 5-methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylic esters was performed and effectively catalyzed by sulfamic acid. Compared with conventional methods, this protocol features mild reaction conditions and high yields. Furthermore, it is solvent-free and thus eco-friendly.

A review of syntheses of 1,5-disubstituted tetrazole derivatives

Abstract: This report provides a brief overview of the various representative literature procedures for the synthesis of 1,5-disubstituted tetrazoles (1,5-DSTs) and fused 1,5-disubstituted tetrazoles with more than 120 references. Most of the published methods for the synthesis of 1,5-DSTs include the use of nitriles, amides, thioamides, imidoyl chlorides, heterocumulenes, isocyanates, isothiocyanates, carbodiimides, ketenimines, ketones, amines, and alkenes as the starting materials. The transformation of 1- and 5-substituted tetrazoles into 1,5-DSTs is also covered in this report.

Iodine catalyzed one-pot multicomponent synthesis of a library of compounds containing tetrazolo[1,5-a]pyrimidine core.

Abstract: Versatile and novel reactions of 5-aminotetrazole with structurally diverse aryl aldehydes and building blocks with active methylene catalyzed by iodine were investigated in a multicomponent one-pot protocol. A series of 5,7-diaryl-4,7-dihydrotetrazolo[1,5-a]pyrimidines C and 5-methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylates D were obtained in moderate to good yields. Further exploration rapidly afforded various E in good to excellent yields; in addition, compound F was also obtained under the same condition. The structures of products were characterized by LC-MS, 1H NMR, 13C NMR, and elemental analysis.

Nano-WO3-supported sulfonic acid: New, efficient and high reusable heterogeneous nano catalyst

Abstract: Nano-WO3-supported sulfonic acid [n-WO3-SO3H (n-WSA)] is easily prepared from the reaction of nano WO3 with chlorosulfonic acid as sulfonating agent. This new catalyst is characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), FT-IR spectroscopy, thermal gravimetric analysis (TGA), pH analysis and Hammett acidity function. Nano-WO3-supported sulfonic acid is used as an efficient and recyclable catalyst for some organic reactions such as synthesis of 1,8-dioxo-octahydroxanthene, tetrahydrobenzoxanthene and benzimidazolo quinazolinone derivatives. All of the reactions are very fast and the yields are excellent. The used catalyst was easily separated and reused for 10 runs without appreciable loss of its catalytic activity.